王淼,研究員,博士生導(dǎo)師。1996年本科畢業(yè)于浙江大學(xué),2002年于北京協(xié)和醫(yī)學(xué)院獲得免疫學(xué)方向博士學(xué)位。在美國賓夕法尼亞大學(xué)藥理系從事博士后研究, 2006年起先后擔(dān)任賓西法尼亞大學(xué)藥理系做研究助理和研究助理教授。 2010起受聘為美國輝瑞制藥全球研發(fā) 心血管與代謝性疾病研發(fā)部項目首席科學(xué)家。2013年就職于中國醫(yī)學(xué)科學(xué)院/北京協(xié)和醫(yī)學(xué)院阜外醫(yī)院(國家心血管病中心)心血管疾病國家重點實驗室和臨床藥理中心。
主要研究方向是心血管疾病炎癥免疫調(diào)節(jié)機制與新藥發(fā)現(xiàn)。發(fā)表主要論文于CirculationResearch、Nature Communications、PNAS、Circulation(2008,2011,2017)、J Clin Invest、ATVB(2018a,2018b, 2019,2020)等學(xué)術(shù)期刊。主編《冠心病:治療與藥物發(fā)現(xiàn)》英文書(Springer出版社,2020)。
1. Wan Q, Xu C, Zhu L, Zhang Y, Peng Z, Chen H, Rao H, Zhang E, Wang H, Chu F, Ning X, Yang X, Yuan J, Wu Y, Huang Y, Hu S, Liu DP, Wang M*. Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation. Circulation Reseach. 2022 July 8. (IF=23.213)
2. Zhang Y, Li H, Huang Y, Chen H, Rao H, Yang G, Wan Q, Peng Z, Bertin J, Geddes B, Reilly M, Tran JL, Wang M * . Stage-Dependent Impact of RIPK1 Inhibition on Atherogenesis: Dual Effects on Inflammation and Foam Cell Dynamics. Front Cardiovasc Med. 2021;8:715337. (IF=5.846)
3. Hao H, Ma X, Chen H, Zhu L, Xu Z, Li Q, Xu C, Zhang Y, Peng Z, Wang M*. The cyclic adenosine monophosphate elevating medicine, forskolin, reduces neointimal formation and atherogenesis in mice. J Cell Mol Med. 2020;24(17):9638-9645. (IF=5.295)
4. Zhu L, Xu C, Huo X, Hao H, Wan Q, Chen H, Zhang X, Breyer RM, Huang Y, Cao X, Liu DP, FitzGerald GA, Wang M*. The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury. Nat Commun. 2019;10(1):1888. (IF=17.694)
5. Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M* .Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury. Arterioscler Thromb Vasc Biol. 2018;38(5):1115-1124.(IF=10.514)
6. Hao H, Hu S, Chen H, Bu D, Zhu L, Xu C, Chu F, Huo X, Tang Y, Sun X, Ding B, Liu D, Hu S, Wang M*. Loss of Endothelial CXCR7 Impairs Vascular Homeostasis, and Cardiac Remodeling After Myocardial Infarction: Implications for Cardiovascular Drug Discovery. Circulation. 2017; 135(13):1253-1264. (IF=39.918)