趙明，研究員，博士研究生導(dǎo)師，長聘副教授。曾獲國家科學(xué)技術(shù)進(jìn)步獎(jiǎng)二等獎(jiǎng)（2017年），湖南省自然科學(xué)獎(jiǎng)一等獎(jiǎng)（2015年）、湖南省科學(xué)技術(shù)進(jìn)步獎(jiǎng)一等獎(jiǎng)（2018年）等國家和省部級科技獎(jiǎng)勵(lì)6項(xiàng)。獲得國家“萬人計(jì)劃”科技創(chuàng)新領(lǐng)軍人才、國家自然科學(xué)基金優(yōu)秀青年基金、科技部中青年科技創(chuàng)新領(lǐng)軍人才、國家自然科學(xué)基金重點(diǎn)項(xiàng)目、江蘇省雙創(chuàng)人才等項(xiàng)目資助。 院校引進(jìn)人才，2022年加入院校，曾在中南大學(xué)湘雅二醫(yī)院（引進(jìn)前單位）任研究員。

長期從事免疫炎癥性皮膚病發(fā)病機(jī)制及診斷與治療研究。揭示了紅斑狼瘡、銀屑病發(fā)病的表觀遺傳學(xué)機(jī)制，研發(fā)國際上首個(gè)紅斑狼瘡DNA甲基化診斷試劑盒（已獲III類醫(yī)療器械證），開發(fā)紅斑狼瘡及銀屑病治療候選新藥物。承擔(dān)9項(xiàng)國家和省部級科研課題，作為通訊作者及第一作者在Journal of Clinical Investigation等雜志發(fā)表論文80余篇，H指數(shù)50，入選2024年“全球前2%頂尖科學(xué)家”。獲得授權(quán)發(fā)明專利17項(xiàng)（已轉(zhuǎn)化2項(xiàng)）。參編專著5部。培養(yǎng)博士、碩士、博士后50余名。

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1. Min X#, Yu Y#, Hu Z, Ouyang L, Qiu Y, Zhao H, Wu J, Zou C, Zheng M, Yang S, Jia S, Yu D, Lu Q*, Zhao M*. DNA demethylation mediated endogenous retroviruses transcription promotes aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway. EBioMedicine. 2025 Oct; 120:105934. (IF= 10.8)

2. Qiu Y#, Jiang W, Feng D, Yu Y, Hou H, Deng M, Chen X, Liu L, Wu R, Lu Q*, Zhao M*. Resolving 3-Dimensional Genomic Landscape of CD4+ T Cells in the Peripheral Blood of Patients with Psoriasis. J Invest Dermatol. 2025 Apr; 145(4):831-841. (IF= 5.7)

3. Yin H#, Li L#, Feng X#, Wang Z, Zheng M, Zhao J, Fan X, Wu W, Gao L, Zhan Y, Zhao M*, Lu Q*. 2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus. Signal Transduct Target Ther. 2024 Nov 17; 9(1):323. (IF= 40.8)

4. Wang L#, Yin H, Jiang J, Li Q, Gao C, Li W, Zhang B, Xin Y, Li H, Zhao M*, Lu Q*. A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus. Acta Pharm Sin B. 2024 Oct;14(10):4560-4576. (IF= 14.7)

5. Jiang W#, Zhang T#, Qiu Y, Liu Q, Chen X, Wang Q, Min X, Ouyang L, Jia S, Lu Q, He Y*, Zhao M*. Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles. Theranostics. 2024 Jan 1;14(3):1049-1064. (IF= 12.4)

6. Zhao M#*, Feng D, Hu L, Liu L, Wu J, Hu Z, Long H, Kuang Q, Ouyang L, Lu Q*. 3D genome alterations in T cells associated with disease activity of systemic lupus erythematosus. Ann Rheum Dis. 2023 Feb;82(2):226-234. (IF=20.3, F1000)

7. Zheng M#, Hu Z#, Mei X#, Ouyang L#, Song Y#, Zhou W, Kong Y, Wu R, Rao S, Long H, Shi W, Jing H, Lu S, Wu H, Jia S, Lu Q*, Zhao M*. Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus. Nat Commun. 2022 Dec 5;13(1):7489. （IF=17.694）

8. Gao X#, Song Y#, Wu J, Lu S, Min X, Liu L, Hu L, Zheng M, Du P, Yu Y, Long H, Wu H, Jia S, Yu D, Lu Q*, Zhao M*. Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus. J Clin Invest. 2022 May 2;132(9):e152345. (IF=15.9)

9. Wu R#, Zeng J#, Yuan J, Deng X, Huang Y, Chen L, Zhang P, Feng H, Liu Z, Wang Z, Gao X, Wu H, Wang H, Su Y, Zhao M*, Lu Q*. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation. J Clin Invest. 2018 Jun 1;128(6):2551-2568. (IF=11.864, ESI, C100)

10. Zhao M#, Zhou Y, Zhu B, Wan M, Jiang T, Tan Q, Liu Y, Jiang J, Luo S, Tan Y, Wu H, Renauer P, Del Mar Ayala Gutiérrez M, Castillo Palma MJ, Ortega Castro R, Fernández-Roldán C, Raya E, Faria R, Carvalho C, Alarcón-Riquelme ME, Xiang Z, Chen J, Li F, Ling G, Zhao H, Liao X, Lin Y, Sawalha AH*, Lu Q*. IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus. Ann Rheum Dis. 2016 Nov;75(11):1998-2006. (IF=12.811, R, C100)