吳志宏，中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)院主任醫(yī)師，外科學(xué)生物醫(yī)學(xué)工程專業(yè)博士生導(dǎo)師，臨床研究所干細胞平臺主任、疑難重癥及罕見病全國重點實驗室PI。曾獲國家科技進步二等獎、中國21世紀(jì)重要醫(yī)學(xué)成就、教育部一等獎、北京市科技進步二等獎、華夏科技進步二等獎等多項省部級以上獎勵。主持國家自然科學(xué)基金重點項目、重點研發(fā)、北自然重點等40余項項目。

長期從事運動系統(tǒng)相關(guān)疾病的遺傳學(xué)病因及其精準(zhǔn)診療，組織建立的“系統(tǒng)解析脊柱側(cè)凸及相關(guān)合并癥（DISCO）”國際多中心協(xié)作組為全面揭示脊柱畸形及相關(guān)疾病的遺傳學(xué)病因及機制、實現(xiàn)脊柱畸形的精準(zhǔn)診療打下堅實基礎(chǔ)。發(fā)現(xiàn)TBX6基因變異是目前為止導(dǎo)致先天性脊柱側(cè)凸的最重要致病因素；鑒定骨骼畸形診療新靶點，研發(fā)生物技術(shù)為基礎(chǔ)的創(chuàng)新型治療方法。共發(fā)表文章300余篇，總IF>700。參加編寫著作14部（副主編3部），獲得授權(quán)專利41項。

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1.Liu J#, Liu F#, Li C#, Li Z, Li T, Wu Y, Wu D, Huang Y, Chen H, Wang H*, Lai Y*, Wu Z*. 3D-printed magnetic scaffolds promote bone and vessel regeneration through CRYAB/PI3K-AKT and NF-κB pathways identified by proteomics. Bioact Mater. 2025; 56:277-293. (IF=20.5)

2.Zhao S#, Zhao H#, Zhao L#, Cheng X#, Zheng Z, Wu M, Wen W, Wang S, Zhou Z, Xie H, Ruan D, Li Q, Liu X, Ou C, Li G, Zhao Z, Chen G, Niu Y, Yin X, Hu Y, Zhang X; Deciphering disorders Involving Scoliosis and COmorbidities (DISCO) study; Liu P, Qiu G, Liu W, Zhao C, Wu Z*, Zhang J*, Wu N*. Unraveling the genetic architecture of congenital vertebral malformation with reference to the developing spine. Nat Commun. 2024; 15(1):1125. (IF=15.7)

3.Wu XD#, Kang L, Tian J, Wu Y, Huang Y, Liu J, Wang H*, Qiu G*, Wu Z*. Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway. Mater Today Bio. 2022; 15:100319. (IF=8.2)

4.Gao Y#, Zhao H#, An K#, Liu Z#, Hai L#, Li R, Zhou Y, Zhao W, Jia Y, Wu N, Li L, Ying J, Wang J, Xu B, Wu Z*, Tong Z*, He J*, Sun Y*. Whole-genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer. Clin Transl Med. 2022; 12(8): e1014. (IF=10.6)

5.Sun L#, Huang Y#, Zhao S, Zhao J, Yan Z, Guo Y, Lin M, Zhong W, Yin Y, Chen Z, Zhang N, Zhang Y, Zhao Z, Li Q, Wang L, Dong X, Li Y, Li X, Qiu G; DISCO (Deciphering Disorders Involving Scoliosis & COmorbidities) study group, Zhang TJ, Wu Z*, Tian W*, Wu N*. Deciphering the mutational signature of congenital limb malformations. Mol Ther Nucleic Acids. 2021; 24:961-970. (IF=10.183)

6.Wu D#, Chang X#, Tian J, Kang L, Wu Y, Liu J, Wu X, Huang Y, Gao B, Wang H*, Qiu G*, Wu Z*. Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis. J Nanobiotechnology. 2021; 19(1):209. (IF=9.429, C100)

7.Leng L#, Cao R#, Ma J#, Mou D#, Zhu Y, Li W, Lv L, Gao D, Zhang S, Gong F, Zhao L, Qiu B, Xiang H, Hu Z, Feng Y, Dai Y, Zhao J, Wu Z*, Li H*, Zhong W*. Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples. Signal Transduct Target Ther. 2020; 5(1):240. (IF=18.187)

8.Huang Z#, He Y#, Chang X#, Liu J, Yu L, Wu Y, Li Y, Tian J, Kang L, Wu D, Wang H*, Wu Z*, Qiu G. A Magnetic Iron Oxide/Polydopamine Coating Can Improve Osteogenesis of 3D-Printed Porous Titanium Scaffolds with a Static Magnetic Field by Upregulating the TGFβ-Smads Pathway. Adv Healthc Mater. 2020; 9(14). (IF=9.933)

9.Wu D#, Kang L, Tian J, Wu Y, Liu J, Li Z, Wu X, Huang Y, Gao B, Wang H*, Wu Z*, Qiu G. Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of Fe3O4 Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p. Int J Nanomedicine. 2020; 15:7979-7993. (IF=6.4, C100)

10.Wu N#, Ming X#, Xiao J#, Wu Z#, Chen X#, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev Z S, Liu S, Yang N, Al-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Shen J, Chen Y, Zhang T, Zhang J, Choy K W, Wang J, Wang Q, Li S, Zhou W, Guo J, Wang Y, Zhang C, Zhao H, An Y, Zhao Y, Wang J, Liu Z, Zuo Y, Tian Y, Weng X, Sutton V R, Wang H, Ming Y, Kulkarni S, Zhong T P, Giampietro P F, Dunwoodie S L, Cheung S W, Zhang X, Jin L, Lupski J R, Qiu G*, Zhang F*. TBX6 null variants and a common hypomorphic allele in congenital scoliosis. N Engl J Med. 2015; 372(4):341-50. (IF=59.558, C100, F1000)