張?zhí)焯?，研究員，博士研究生導(dǎo)師。本科、碩士均畢業(yè)于蘭州大學(xué)醫(yī)學(xué)部，獲得醫(yī)學(xué)學(xué)士和碩士學(xué)位。2003年博士畢業(yè)于中國藥科大學(xué)藥理學(xué)專業(yè)。2003年進(jìn)入中國醫(yī)學(xué)科學(xué)院藥物研究所從事博士后研究，2006年進(jìn)入中國醫(yī)學(xué)科學(xué)院藥物研究所工作，主要從事抗炎免疫藥理學(xué)及新藥發(fā)現(xiàn)研究。曾獲北京市科學(xué)技術(shù)獎二等獎2項(xiàng)、中華醫(yī)學(xué)科技獎二、三等獎各1項(xiàng)。

長期從事抗炎免疫藥理學(xué)及新藥發(fā)現(xiàn)研究，致力于炎癥及自身免疫性疾病的發(fā)病機(jī)制及免疫調(diào)控研究，利用生物分子事件尋找新的藥物作用靶點(diǎn)和新藥研究。主持研發(fā)的治療自身免疫性疾病化學(xué)1類新藥--選擇性JAK3抑制劑，獲得中國及美國專利授權(quán)，并于2025年實(shí)現(xiàn)了成果轉(zhuǎn)化。

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1. Yi Zhang^#, Yanqi Han, Ying Sun, Longhui Hao, Yue Gao, Jun Ye, Hongliang Wang, Tiantai Zhang*, Yuling Liu*, Yanfang Yang*. Osteoarthritis: molecular pathogenesis and potential therapeutic options. Signal Transduct Target Ther. 2026, DOI:10.1038/s41392-025-02556-6. (IF=52.7)

2. Gaona Shi^#, Xiang Liu^#, YaziWei^#, Yu Zhou, Xuefeng Gao, Chengjuan Chen, Junjie Yang, Weiwei Wang*, Lan Sun*, Tiantai Zhang*. Immunomodulatory supramolecular hydrogel for rheumatoid arthritis management via adenosine A2A receptor-mediated macrophage remodeling. Bioact Mater. 2026, 58:139-56. (IF=20.3)

3. Yifan Feng^#, Chengjuan Chen^#, Anqi Shao, Qingyang Zhang, Lan Sun*, Haiyu Hu*, Tiantai Zhang*. Recent advances in interleukin1 receptor-associated kinase 4 (IRAK4) inhibitors and PROTACs. Chin Chem Lett. 2025, 36(12):110936. (IF=8.9)

4. Yifan Feng^#, Chengjuan Chen^#, Anqi Shao, Lei Wu, Haiyu Hu*, Tiantai Zhang*. Emerging interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer. Acta Pharm Sin B. 2024, 14(12): 5091-105. (IF=14.6)

5. Shuai Shao^#, Chengjuan Chen^#, Gaona Shi, Yu Zhou, Yazi Wei, Lei Wu, Lan Sun*, Tiantai Zhang*. JAK inhibition ameliorated EAE by blocking GM-CSF-driven inflammatory signature of monocytes. Acta Pharm Sin B.  2023, 13(10):4185-201. (IF=14.8)

6. Gaona Shi^#, Yu Zhou, Wenshuai Liu, Chengjuan Chen, Yazi Wei, Xinlong Yan, Lei Wu, Weiwei Wang*, Lan Sun*, Tiantai Zhang*. Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells. Acta Pharm Sin B. 2023, 13(6):2778-94. (IF=14.8)

7. Chengjuan Chen^#, Yuan Yin, Gaona Shi, Yu Zhou, Shuai Shao, Yazi Wei, Lei Wu, Dayong Zhang*, Lan Sun*, Tiantai Zhang*. A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokines related JAK-STAT signal. Sci Adv. 2022, 8(33):eabo4363. (IF=13.6)

8. Shuai Shao^#, Chengjuan Chen, Gaona Shi, Yu Zhou, Yazi Wei, Ningyu Fan, Yan Yang, Lei Wu, Tiantai Zhang*. Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis. Pharmacol Ther.  2021, 227: 107880. (IF=13.4)

9. Shuai Shao^#, Chengbo Xu^#, Chengjuan Chen, Gaona Shi, Qinglan Guo, Yu Zhou, Yazi Wei, Lei Wu, Jiangong Shi*, Tiantai Zhang*. Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice. J Neuroinflamm. 2021, 18:142. (IF=9.594)

10. Qinglan Guo^#, Huan Xia^#, Yuzhuo Wu, Shuai Shao, Chengbo Xu, Tiantai Zhang*, Jiangong Shi*. Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from Aconitum carmichaelii. Acta Pharm Sin B. 2020, 10(10):1954-65. (IF=11.614)