譚忠平，1975年生，籍貫山東濰坊，中國醫(yī)學科學院藥物研究所研究員，博士生導(dǎo)師。1992年考入北京大學有機化學專業(yè)，1997年獲得學士學位。1997-2000年在北京大學攻讀有機化學碩士學位，從事有機方法學研究。2000-2005年在哥倫比亞大學攻讀化學生物學博士學位，從事核糖體表達多肽的研究。2005年進入紀念斯隆-凱特琳癌癥中心從事博士后研究，研究糖蛋白的制備技術(shù)。2011-2018年在科羅拉多大學擔任助理教授，探索糖基化的作用。2018年至今，在藥物研究所任研究員。

開發(fā)新的策略，對糖蛋白異型體的化學合成和表征進行深入研究，真正了解蛋白糖基化構(gòu)效關(guān)系。通過實驗和計算模擬，優(yōu)化和驗證可用于指導(dǎo)藥用多肽、蛋白糖基化改造的原則。糖蛋白混合物組成和功能關(guān)系的定量分析。

午夜92福利1000,午夜92福利1000,久久国产亚洲高清观看5388,美女不拍网站免费观看,欧美***天天久久综合精品,中文字幕日韩系列中文字幕,综合久久国产九一剧情麻豆,丰满人妻在线免费视频,奶子大逼又嫩操起来真爽

1. Wei Hao#, Bo Ma#, Ziheng Li, Xiaoyu Wang, Xiaopan Gao, Yaohao Li, Bo Qin, Shiying Shang, Sheng Cui*, Zhongping Tan*. Binding of the SARS-CoV-2 Spike Protein to Glycans. Science Bulletin, 2021, 66(12): 1205–1214. (IF=20.577)

2.Yaohao Li#, Xiaoyang Guan#, Patrick K. Chaffey#, Yuan Ruan, Bo Ma, Shiying Shang, Michael E. Himmel, Gregg T. Beckham, Hai Long*, Zhongping Tan*. Carbohydrate-binding module O-mannosylation alters binding selectivity to cellulose and lignin. Chem. Sci., 2020, 11(34): 9262–9271. (IF=9.825)

3.Erica T. Prates#, Xiaoyang Guan, Yaohao Li, Xinfeng Wang, Patrick K. Chaffey, Munir S. Skaf, Michael F. Crowley, Zhongping Tan*, Gregg T. Beckham*. The impact of O-glycan chemistry on the stability of intrinsically disordered proteins. Chem. Sci., 2018, 9(15): 3710–3715. (IF=9.556)

4. Xiaoyang Guan#, Patrick K. Chaffey#, Xiuli Wei#, Daniel R Gulbranson#, Yuan Ruan, Xinfeng Wang, Yaohao Li, Yan Ouyang, Liqun Chen, Chen Zeng, Theo N. Koelsch, Amy H. Tran, Wei Liang*, Jingshi Shen*, Zhongping Tan*. Chemically Precise Glycoengineering Improves Human Insulin. ACS Chem. Biol. 2018, 13(1): 73–81. (IF=4.374, F1000)

5. Xiaoyang Guan#, Patrick K. Chaffey#, Huan Chen#, Wei Feng#, Xiuli Wei, Liu-Meng Yang, Yuan Ruan, Xinfeng Wang, Yaohao Li, Kimberly B. Barosh, Amy H. Tran, Jaimie Zhu, Wei Liang, Yong-Tang Zheng*, Xu Wang*, Zhongping Tan*. O?GalNAcylation of RANTES Improves Its Properties as a Human Immunodeficiency Virus Type 1 Entry Inhibitor. Biochemistry, 2018, 57(1): 136–148. (IF=2.952)

6. Patrick K. Chaffey#, Xiaoyang Guan, Yaohao Li, Zhongping Tan*. Using Chemical Synthesis To Study and Apply Protein Glycosylation. Biochemistry, 2018, 57(4): 413–428. (IF=2.952)

7. Xiaoyang Guan#, Patrick K. Chaffey#, Chen Zeng#, Eric R. Greene, Liqun Chen, Matthew R. Drake, Claire Chen, Ari Groobman, Michael G. Resch, Michael E. Himmel, Gregg T. Beckham*, Zhongping Tan*. Molecular-scale features that govern the effects of O-glycosylation on a carbohydrate-binding module. Chem. Sci., 2015, 6(12): 7185–7189. (IF=9.144)

8. Liqun Chen#, Matthew R. Drakea#, Michael G. Resch#, Eric R. Greene#, Michael E. Himmel, Patrick K. Chaffey, Gregg T. Beckham*, Zhongping Tan*. Specificity of O-glycosylation in enhancing the stability and cellulose binding affinity of Family 1 carbohydrate-binding modules. Proc. Natl. Acad. Sci. U. S. A., 2014, 111(21): 7612–7617. (IF=9.674)

9. Zhongping Tan#, Shiying Shang, Samuel J. Danishefsky*. Insights into the Finer Issues of Native Chemical Ligation: An Approach to Cascade Ligations. Angew. Chem. Int. Ed. 2010, 122(49): 4835–4839. (IF=12.730)

10. Zhongping Tan#, Shiying Shang, Tamara Halkina, Yu Yuan, Samuel J. Danishefsky*. Toward Homogeneous Erythropoietin: Non-NCL-Based Chemical Synthesis of the Gln⁷⁸-Arg¹⁶⁶ Glycopeptide Domain. J. Am. Chem. Soc. 2009, 131(15): 5424–5431. (IF=8.580)