宋丹青，1964年生，籍貫山東棲霞，藥物化學專家，醫(yī)藥生物技術研究所研究員，博士生導師。1982年考入北京師范大學化學專業(yè)，1986年獲得學士學位。1986-1989年在北京師范大學有機化學專業(yè)攻讀碩士學位，從事有機合成研究。2003-2008年在北京協和醫(yī)學院微生物與生化專業(yè)攻讀在職博士，從事藥物化學研究。1992年升為助理研究員。1997年為副研究員。

抗感染、抗腫瘤與抗代謝藥物的化學基礎、化學生物學機制與新藥研發(fā)。對活性天然產物開展理性結構改造，解析化學小分子與生物大分子的直接靶標與鍵合機制，尋找結構新穎、機制獨特的創(chuàng)新藥物。

午夜92福利1000,午夜92福利1000,久久国产亚洲高清观看5388,美女不拍网站免费观看,欧美***天天久久综合精品,中文字幕日韩系列中文字幕,综合久久国产九一剧情麻豆,丰满人妻在线免费视频,奶子大逼又嫩操起来真爽

1.Li Y#, Zhang Y#, Niu T, Pang Y, Shi Y, Zen Q, Zhang J, Zhu J, Zhong X, Wang Y, Wang Y, Tang S, Kong W*, and Song D*, and Jiang J*. Discovery and Development of Tricyclic Matrinic Derivatives as Anti-diabetic Candidates by AMPKα Activation. Chinese Chemical Letters DOI: 10.1016/j.cclet.2022.05.075. (IF=8.455)

2. Fan T, # Cheng Y#, Wei W#, Zeng Q, Guo X, Guo Z, Li Y, Zhao L, Shi Y, Zhang X, Jiang J, Wang Y*, Kong W*, and Song D*. Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3-Kinase/Akt Phosphorylation. Journal of Medicinal Chemistry 2022 65(10): 7399–413. (IF=8.039)

3. Zhang X#, Shi Y#, Guo Z#, Zhao X, Wu J, Cao S, Liu Y, Li Y, Huang W, Wang Y, Liu Q, Li Y*, and Song D*. Clofazimine Derivatives as Potent Broad-spectrum Antiviral Agents with Dual-target Mechanism. European Journal of Medicinal Chemistry 2022 234: 114209-18. (IF=7.088)

4. Zeng Q#, Deng H#, Li Y#, Fan T, Liu Y, Tang S, Wei W, Liu X, Guo X, Jiang J, Wang Y,* and Song D*. Berberine Directly Targets the NEK7 Protein to Block the NEK7?NLRP3 Interaction and Exert Anti-inflammatory Activity. Journal of Medicinal Chemistry 2021 64(10): 768–81 (IF=8.039)

5.Tang S#, Wang C#, Li Y, Niu T, Zhang Y, Pang Y, Wang Y, Kong W*, and Song D*. Structure-Activity Relationship and Hypoglycemic Activity of Tricyclic Matrines with Advantage of Treating Diabetic Nephropathy. European Journal of Medicinal Chemistry 2020 201; 112315-24. (IF=6.514)

6. Zhang N#, Dou Y#, Liu L, Zhang X, LiuX, Zeng Q, Liu Y, Yin Ma, Liu X, Deng H^?, and Song D*. SA-49, A Novel Aloperine Derivative, Induces MITF-dependent Lysosomal Degradation of PD-L1. EBioMedicine 2019, 40: 151–62. (IF=5.736)

7. Yang Y#, Lu X#, Zeng Q, Pang J, Fan T, You X, Tang S, Wang Y*, and Song D*. Synthesis and Biological Evaluation of 7-Substituted Cycloberberine Derivatives as Potent Antibacterial Agents against MRSA. European Journal of Medicinal Chemistry 2019 168; 283–92. (IF=5.573)

8. Peng Z#, Fan B, Du N#, Wang Y, Gao L, Li Y, Li Y, Liu F, You X, Han Y, Zhao Z, Cen S, Li J, Song D*, and Jiang J*. Small Molecular Compounds that Inhibit Hepatitis C Virus Replication through Destabilizing Heat Shock Cognate 70 Messenger RNA. Hepatology, 2010, 52(3): 845–53.  (IF=11.665)

9. Zhang X#, Liu Q#, Li Q, Li Y, Liu Z, Deng H, Tang S, Wang Y, Wang Y*, and Song D*. Synthesis and Biological Evaluation of Novel Tricyclic Matrinic Derivatives as Potential Anti-filovirus Agents. Acta Pharm Sin B 2018, 8: 629–38.  (IF=6.014)

10. Gao L#, Han Y#, Wang Y, Li Y, Shan Y, Li X, Peng Z, Bi C, Zhang Tian, Du Na-Na, Jiang J*, and Song D*. Design and Synthesis of Oxymatrine Analogues Overcoming Drug Resistance in Hepatitis B Virus through Targeting Host Heat Stress Cognate 70. Journal of Medicinal Chemistry 2011, 54(3): 869–76. (IF=5.248)