張建民，研究員，博士研究生導(dǎo)師，“協(xié)和學(xué)者”特聘教授，現(xiàn)就職于中國(guó)醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所免疫學(xué)系。畢業(yè)于中國(guó)協(xié)和醫(yī)科大學(xué)，曾先后在耶魯大學(xué)和約翰霍普金斯大學(xué)醫(yī)學(xué)院任博士后、講師、助理教授。北京市政協(xié)委員，農(nóng)工民主黨中央委員，享受國(guó)務(wù)院政府特殊津貼。曾獲北京市科技進(jìn)步一等獎(jiǎng)1項(xiàng)，中華醫(yī)學(xué)科技獎(jiǎng)一等獎(jiǎng)2項(xiàng)。獲得國(guó)家自然基金、科技部行業(yè)專項(xiàng)、十三五、十四五重點(diǎn)研發(fā)計(jì)劃等項(xiàng)目資助。

長(zhǎng)期致力于神經(jīng)系統(tǒng)炎癥性疾病和腫瘤發(fā)病機(jī)制和治療性靶點(diǎn)探索，著眼于T細(xì)胞，探究其在免疫監(jiān)視中的作用及機(jī)制，基于其功能特點(diǎn)開展炎癥性疾病和腫瘤的免疫治療新策略研究。秉持“臨床痛點(diǎn)-基礎(chǔ)研究-臨床轉(zhuǎn)化”的主旨思路，注重以臨床應(yīng)用場(chǎng)景為導(dǎo)向的科技研發(fā)，開展了多項(xiàng)細(xì)胞免疫治療的臨床試驗(yàn)。研究成果發(fā)表在百余篇國(guó)際科學(xué)雜志上，其中作為第一作者/通訊作者包括Cell（封面），Nature Immunology，Cell Discovery，STTT等90余篇國(guó)際著名雜志。

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1.Menghua Cai#, Feng Tian#, Jingyi Han, Liang Wang, Shikai Hu, Peng Dong, Wenhua Qiao, Han Zhang, Yue Wang, Hui Chen*, Wei He*, Jianmin Zhang*. Genetically engineered extracellular vesicles expressing decoy protein TACI provide a therapeutic effect in systemic lupus erythematosus mouse model. Journal of Controlled Release. 2025, 384:113886. (IF=11.5)

2.Hongqin You#, Xiangjin Zhang#, Hui Chen#, Chang Liu#, Da Teng#, Jiajia Han#, Ming Chen#, Yongsheng Pang#, Jianmin Zhang#, Menghua Cai , Yueqi Zhao, Qingqing Dong , Shuli Wang , Yi Xu, Yu Hu, Peng Dong and Wei He*. γδ T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition. Cellular & Molecular Immunology; 2025 Apr;22(4):356-370. (IF=21.8)

3.Han Zhang#, Menghua Cai#, Fei Gao#, Jia Yang#, Chao Li#, Jingyi Han, Yue Wang, Yi Xu, Yu Hu, Hui Chen*, Wei He*, Jianmin Zhang*. Thorase deficiency causes both Aβ accumulation and tau hyperphosphorylation in mouse brain. Alzheimer’s Dement. 2024;1–18. (IF=13.1)

4.Yue Wang#, Jingyi Han, Dongdong Wang, Menghua Cai, Yi Xu, Yu Hu, Hui Chen, Wei He* and Jianmin Zhang*. Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer. Signal Transduct Targeted Ther 2023, 8(1):399. (IF=39.3)

5.Jiajia Han#, Na Liu, Wenwen Jin, Peter Zanvit, Dunfang Zhang, Junji Xu, Andrew Bynum, Rida Kazmi, Jianmin Zhang*, Wei He*, WanJun Chen*. TGF-β controls development of TCRγδ+CD8αα+ intestinal intraepithelial lymphocytes, Cell discovery 2023, 9(1): 52. (IF=38.079)

6.Weiqing Wang#, Yi Xu#, Lun Wang#, Zhenzhen Zhu, Surita Aodeng, Hui Chen, Menghua Cai, Zhihao Huang, Jinbo Han, Lei Wang, Yuxi Lin, Yu Hu, Liangrui Zhou, Xiaowei Wang, Yang Zha, Weihong Jiang, Zhiqiang Gao, Wei He*, Wei Lv*, Jianmin Zhang*. Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis. Nature Immunology 2022, 23(10): 1484-1494 (IF=31.25, C100)

7.Yuli Zhu#, Siya Zhang#, Zinan Li, Huaishan Wang, Zhen Li, Yu Hu, Hui Chen, Xuan Zhang, Lianxian Cui, Jianmin Zhang*, Wei He*. miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity. Cell Mol Immunol 2019, 16(2):112-125. (IF=22.096)

8.Hui Chen#, Mingjin Zou#, Da Teng#, Yu Hu, Jianmin Zhang*, Wei He*. Profiling the pattern of the human T-cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis. Cell Mol Immunol 2019, 6(3):250-259. (IF=22.096)

9.Zhen Li#, Yanmei Jiao, Yu Hu, Lianxian Cui, Dexi Chen, Hao Wu, Jianmin Zhang*, Wei He*. Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection. Cell Mol Immunol 2015, 12(5):604-14. (IF=22.096)

10.Jianmin Zhang#, Yue Wang, Zhikai Chi, Matthew J. Keuss, Ying-Min Emily Pai, Ho Chul Kang, Jooho Shin, Artem Bugayenko, Hong Wang, Yulan Xiong, Mikhail V. Pletnikov, Mark P. Mattson, Ted M. Dawson*, Valina L. Dawson*. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell 2011,145 (2):284-299. (IF=66.85, F1000)