陳杰，1955年生，籍貫黑龍江巴彥縣，病理學(xué)專(zhuān)家，北京協(xié)和醫(yī)院教授，主任醫(yī)師，博士生導(dǎo)師，北京協(xié)和醫(yī)學(xué)院病理學(xué)系主任。1973年考入哈爾濱醫(yī)科大學(xué)醫(yī)療系，1977年獲得學(xué)士學(xué)位。1978年在中國(guó)協(xié)和醫(yī)科大學(xué)病理學(xué)專(zhuān)業(yè)攻讀碩士學(xué)位，1987年攻讀博士學(xué)位。曾留學(xué)英國(guó)和美國(guó)，從事病理學(xué)研究。1991年升為副研究員。1994年升為主任醫(yī)師、博士生導(dǎo)師。

主要從事胰腺腫瘤等人體腫瘤的分子病理學(xué)研究，包括腫瘤的發(fā)生機(jī)制、形態(tài)特點(diǎn)、分子改變、以及生物學(xué)特性等。

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1. .Chen X, Ma H, Mo S, Zhang Y, Lu Z, Yu S, Chen J*. Analysis of the OX40/OX40L immunoregulatory axis combined with alternative immune checkpoint molecules in pancreatic ductal adenocarcinoma. Front Immunol. 2022 Jul 22;13:942154. (IF=8.786)

2.Chen X, Mo S, Zong L, Yu S, Lu Z, Chen J*. A novel signature based on m6A RNA methylation regulators reveals distinct prognostic subgroups and associates with tumor immunity of patients with pancreatic neuroendocrine neoplasms. Neuroendocrinology. 2022 May 24. (IF=5.135)

3.Chen X, Mo S, Zhang Y, Ma H, Lu Z, Yu S, Chen J*. Analysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma. J Pathol Clin Res. 2022 May;8(3):268-278. (IF=5.638)

4. Liju Zong,Shengwei Mo, Shuangni Yu, Yuncan Zhou, Ming Zhang, Jie Chen*, Yang Xiang*. Expression of the immune checkpoint VISTA in breast cancer. Cancer Immunology, Immunotherapy (2020) 69:1437–1446. (IF=6.968)

5. Jie Yan, Shuangni Yu, Congwei Jia,Min Li, Jie Chen*. Molecular subtyping in pancreatic neuroendocrine neoplasms: new in sightsinto clinical, pathological unmet needs and challenges. Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188367. (IF=10.680)

6. H Yang, P Liu, J Zhang, X Peng, Z Lu, S Yu, Y Meng, W-M Tong and J Chen*.Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negativelyregulated by miR-193b. Oncogene (online, 2015.11). 2016, 35:3647–365. (IF=7.932, C100)

7.Yihui Ma, Shuangni Yu, Wugan Zhao, Zhaohui Lu, Jie Chen* .  miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2. Cancer Letters 2010; 298:150-158. (IF=4.864, C100)

8. Shuangni Yu, Zhaohui Lu, Changzheng Liu, Yunxiao Meng, Yihui Ma,Wugan Zhao, Jianping Liu, Jia Yu，and Jie Chen*.  miRNA-96 Suppresses KRAS and Functions as a Tumor Suppressor Gene in Pancreatic Cancer. Cancer Res  2010;70(14):6015-25. (IF=8.234, C100)

9. Wugan Zhao, Shuangni Yu, Zhaohui Lu, Yihui Ma, Yumei Gu, Jie Chen*. The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS. Carcinogenesis. 2010; 31(10):1726-1733. (IF=5.402, C100)

10.Chen Jie# and Baithun SI. Morphological study of 391 cases of exocrine pancreatic tumors with special reference to the classification of exocrine pancreatic carcinomas.  J Pathol 1985; 146:17-2. (IF=9.883, C100)