趙玉沛，1954年生，籍貫吉林懷德，外科醫(yī)學(xué)家，中國(guó)科學(xué)院院士，北京協(xié)和醫(yī)院名譽(yù)院長(zhǎng)，教授，主任醫(yī)師，博士生導(dǎo)師。1978年考入白求恩醫(yī)科大學(xué)醫(yī)學(xué)系醫(yī)學(xué)專業(yè)，1982年獲得學(xué)士學(xué)位。1985年在中國(guó)協(xié)和醫(yī)科大學(xué)外科學(xué)專業(yè)攻讀碩士學(xué)位，從事臨床醫(yī)學(xué)專業(yè)研究。1993年升為副主任醫(yī)師。1995年升為主任醫(yī)師。

在胰腺腫瘤的轉(zhuǎn)化研究與外科診治領(lǐng)域深耕多年，對(duì)胰腺癌、胰腺內(nèi)分泌腫瘤及胰腺囊性腫瘤等胰腺疾病的發(fā)病機(jī)制、早期診斷以及綜合治療等難點(diǎn)問題進(jìn)行了深入的臨床與基礎(chǔ)研究，取得了系統(tǒng)性和開創(chuàng)性的成果。

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1. Dai M#*, Liu Q#, Xing C#, Tian X#, Cao F#, Tang W#, Lv S, Ma Y, Zhang D, Kleeff J, Yang Y, Liu R, He Q, Li F, Li G, Guo J, Liao Q, Zhao Y*. Early Drain Removal is Safe in Patients With Low or Intermediate Risk of Pancreatic Fistula After Pancreaticoduodenectomy: A Multicenter, Randomized Controlled Trial. Ann Surg. 2022 Feb 1;275(2):e307-e314.

2. Ren B#, Yang J#, Wang C, Yang G, Wang H, Chen Y, Xu R, Fan X, You L*, Zhang T*, Zhao Y*. High-resolution Hi-C maps highlight multiscale 3D epigenome reprogramming during pancreatic cancer metastasis. J Hematol Oncol. 2021 Aug 4;14(1):120.

3. Wang C, Zhang T, Liao Q, Dai M, Guo J, Yang X, Tan W, Lin D*, Wu C*, Zhao Y*. Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation. Protein Cell. 2021 Feb;12(2):128-144.

4. Li Y#, He Y#, Peng J#, Su Z, Li Z, Zhang B, Ma J, Zhuo M, Zou D, Liu X, Liu X, Wang W, Huang D, Xu M, Wang J, Deng H, Xue J, Xie W, Lan X, Chen M, Zhao Y*, Wu W*, David CJ*. Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer. Nat Cancer. 2021 Jan;2(1):49-65.

5. Yu X#, Hu Y#, Wang Z, He X, Xin S, Li G, Wu S, Zhang Q, Sun H, Lei G, Han W, Xue F, Wang L, Jiang J*, Zhao Y*. Developing a toolbox for identifying when to engage senior surgeons in emergency general surgery: A multicenter cohort study. Int J Surg. 2021 Jan;85:30-39.

6. Hong X#, Qiao S#, Li F, Wang W, Jiang R, Wu H, Chen H, Liu L, Peng J, Wang J, Jia C, Liang X, Dai H, Jiang J, Zhang T, Liao Q, Dai M, Cong L, Han X, Guo D, Liang Z, Li D, Zheng Z, Ye C, Li S, Zhao Y*, Wu K*, Wu W*. Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification system. Gut. 2020 May;69(5):877-887.

7. Ricciardiello F#, Gang Y#, Palorini R, Li Q, Giampà M, Zhao F, You L, La Ferla B, De Vitto H, Guan W, Gu J, Zhang T*, Zhao Y*, Chiaradonna F*. Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation. Oncogene. 2020 May;39(20):4103-4117.

8. Zhang S, Chen L, Zhang Z, Zhao Y*. Orphan drug development in China: progress and challenges. Lancet. 2019 Sep 28;394(10204):1127-1128.

9. Peng J#, Sun BF#, Chen CY#, Zhou JY#, Chen YS#, Chen H, Liu L, Huang D, Jiang J, Cui GS, Yang Y, Wang W, Guo D, Dai M, Guo J, Zhang T, Liao Q, Liu Y, Zhao YL, Han DL, Zhao Y*, Yang YG*, Wu W*. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Cell Res. 2019 Sep;29(9):725-738.

10. Xiong G#, Liu C#, Yang G#, Feng M, Xu J, Zhao F, You L, Zhou L, Zheng L, Hu Y, Wang X*, Zhang T*, Zhao Y*. Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer. J Hematol Oncol. 2019 Sep 12;12(1):97.