庾石山，博士，研究員，博士生導師。1993年畢業(yè)于中國協(xié)和醫(yī)科大學藥物化學專業(yè)獲理學博士學位，1995-1996年在奧地利維也納大學作博士后研究。現(xiàn)任藥物研究所副所長、“天然藥物活性物質與功能”國家重點實驗室主任。杰青、國家級重大人才項目入選者（教育部）、國家衛(wèi)生計生委“有突出貢獻的中青年專家”。主要從事天然藥物化學和創(chuàng)新藥物研究，在中草藥（包括瀕危動物藥材）活性物質的化學研究、新藥創(chuàng)制及重大原創(chuàng)藥物的成果轉化等方面取得系統(tǒng)性和原創(chuàng)性成果。

主要從事瀕危動物藥材和有毒藥用植物中新穎結構藥效分子的發(fā)現(xiàn)、結構與功能及創(chuàng)新藥物研究，具體包括：瀕危動物藥材藥效物質及原創(chuàng)替代品研究；顯著活性小分子天然產(chǎn)物的化學生物學研究；基于天然產(chǎn)物的原創(chuàng)藥物研究。

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1. Sheng Liu, Chunyan Wei, Tian Liu, Shuang-Gang Ma, Chen Chen, Hao Lin, Lianhui Zhang, Heng Wang*, Chong-Jing Zhang* & Shi-Shan Yu*. A heme-activatable probe and its application in the high-throughput screening of Plasmodium falciparum ring-stage inhibitors. Signal Transd. Target. Ther. 2022,7,160. (IF=38.126)

2. Ru-Bing Wang#, Shuang-Gang Ma#*, Cooper S. Jamieson#, Rong-Mei Gao, Yun-Bao Liu, Yong Li, Xiao-Jing Wang, Yu-Huan Li, Kendall N. Houk*, Jing Qu* and Shi-Shan Yu*. Library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity. Chem. Sci. 2021,12,7003-7011. (IF=9.969)

3. Yong Li, Yu-Xun Zhu, Zhao-Xin Zhang, Li Li, Yun-Bao Liu, Jing Qu, Shuang-Gang Ma, Shi-Shan Yu*. Antinociceptive grayanane-derived diterpenoidsfrom flowers of Rhododendron mole. Acta Pharm. Sin. B. 2020,10(6),1073-1082. (IF=11.614)

4. Chunyan Wei#, Cheng-Xiao Zhao#, Sheng Liu#, Jin-Hui Zhao#, Zi Ye, Heng Wang*, Shi-Shan Yu* and Chong-Jing Zhang*. Activity-based protein profiling reveals that secondary-carbon-centered radicals of synthetic 1,2,4-trioxolanes are predominately responsible for modification of protein targets in malaria parasites. Chem. Commun. 2019,55(64),9535-9538. (IF=5.996)

5. Jian Bai#, Dao-Jiang Yan#, Tao Zhang, Yong-Zhi Guo, Yun-Bao Liu, Yi Zou, Man-Cheng Tang, Bing-Yu Liu, Qiong Wu, Shi-Shan Yu*, Yi Tang*, You-Cai Hu*. A Cascade of Redox Reactions Generates Complexityin the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew. Chem. Int. Edit. 2017,56(17),4782-4786. (IF=12.102, F1000)

6. Chang-Shan Niu, Yong Li, Yun-Bao Liu, Shuang-Gang Ma, Fei Liu, Li Li, Song Xu, Xiao-Jing Wang, Ru-Bing Wang, Jing Qu*, Shi-Shan Yu*. Pierisketolide A and Pierisketones B and C, Three Diterpenes with an Unusual Carbon Skeleton from the Roots of Pieris formosa. Org. Lett. 2017,19(4),906-909. (IF=6.492)

7. Fang-Yi Su, Zheng Zhao, Shuang-Gang Ma, Ru-Bing Wang, Yong Li, Yun-Bao Liu, Yu-Huan Li, Li Li, Jing Qu*, Shi-Shan Yu*. Cnidimonins A-C, Three Types of Hybrid Dimer from Cnidium monnieri: Structural Elucidation and Semisynthesis. Org. Lett. 2017,19,4920-4923. (IF=6.492)

8. Shuang-Gang Ma, Mi Li, Ming-Bao Lin, Li Li, Yun-Bao Liu, Jing Qu*, Yong Li, Xiao-Jing Wang, Ru-Bing Wang, Song Xu, Qi Hou, Shi-Shan Yu*. Illisimonin A, a Caged Sesquiterpenoid with a Tricyclo[5.2.1.01,6]decane Skeleton from the Fruits of Illicium simonsii. Org. Lett. 2017,19,6160-6163. (IF=6.492)

9. Zhong-Hai Tang#, Yun-Bao Liu#, Shuang-Gang Ma#, Li Li, Yong Li, Jian-Dong Jiang, Jing Qu*, Shi-Shan Yu*. Antiviral Spirotriscoumarins A and B: Two Pairs of Oligomeric Coumarin Enantiomers with a Spirodienone-Sesquiterpene Skeleton from Toddalia asiatica. Org. Lett. 2016, 18(19), 5146-5149. (IF=6.579)

10.Ya-Dan Wang#, Xiu-Qi Bao#, Song Xu, Wen-Wen Yu, Sheng-Nan Cao, Jin-Ping Hu, Yong Li, Xiao-Liang Wang, Dan Zhang*, Shi-Shan Yu*. A Novel Parkinson’s Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway. J. Med. Chem. 2016,59(19),9062-9079. (IF=6.259)