游雪甫，1966年生，籍貫江西豐城，抗感染藥物藥理學(xué)家，醫(yī)藥生物技術(shù)研究所研究員，博士生導(dǎo)師。1980年考入江西醫(yī)學(xué)院醫(yī)療系專業(yè)，1985年獲得醫(yī)學(xué)學(xué)士學(xué)位。1987年在中國協(xié)和醫(yī)科大學(xué)微生物與生化藥學(xué)系攻讀碩士學(xué)位，從事抗菌藥物藥理學(xué)研究。1993年升為助理研究員，1998年為副研究員，2004年為研究員，2009年為博士生導(dǎo)師，2020年為長聘教授。

抗耐藥菌/超級細菌藥物的發(fā)現(xiàn)與研發(fā)、細菌耐藥/致病機制、抗菌藥物的藥效、藥代、PK/PD評價。

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1. Han Qiao#, Jie Yu, Xiukun Wang, Tongying Nie, Xinxin Hu, Xinyi Yang, Congran Li*, and Xuefu You*. Effect of Different Tolerable Levels of Constitutive mcr-1 Expression on Escherichia coli. Microbiol Spectr. 2022, accepted (IF=9.043)

2. Lang Sun#, Youwen Zhang, Tanxi Cai, Xue Li, Na Li, Zhensheng Xie, Fuquan Yang*, and Xuefu You*. CrrAB regulates PagP-mediated glycerophosphoglycerol palmitoylation in the outer membrane of Klebsiella pneumoniae. J Lipid Res. 2022 Jul 13:100251. doi:10.1016/j.jlr.2022.100251. Online ahead of print (IF =6.676)

3. Yun Lu#, Xinxin Hu, Jing Pang, Xiukun Wang, Guoqing Li, Congran Li, Xinyi Yang, and Xuefu You*. Parallel Reaction Monitoring Mass Spectrometry for Rapid and Accurate Identification of β-Lactamases Produced by Enterobacteriaceae. Front Microbiol. 2022 Jun 20;13:784628. doi:10.3389/fmicb. 2022.784628. eCollection 2022 (IF=6.064)

4. Yue Li#, Yifan Ouyang#, Han Wu#, Peng Wang, Yu Huang, Xue Li, Hongtong Chen, Yu Sun, Xinxin Hu, Xiukun Wang, Guoqing Li, Yun Lu, Congran Li, Xi Lu, Jing Pang, Tongying Nie, Xiaohong Sang, Luyao Dong, Wenting Dong, Jiandong Jiang, Ian C. Paterson, Xinyi Yang*, Wei Hong*, Hao Wang*, and Xuefu You*. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur J Med Chem. 2022 Jan 15; 228:113979. doi: 10.1016/j.ejmech.2021.113979. Epub 2021 Nov 11. PMID: 34802838 (IF=7.088)

5. Lilan Sun#, Lang Sun, Xue Li, Xinxin Hu, Xiukun Wang, Tongying Nie, Youwen Zhang*, and Xuefu You*. A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae. Front Cell Infect Microbiol. 2022 Jan 5;11:809542. doi: 10.3389/fcimb.2021.809542. eCollection 2021.PMID: 35071055 (IF =6.073)

6. Yun Lu#, Xinxin Hu, Tongying Nie, Xinyi Yang, Congran Li, and Xuefu You*. Strategies for Rapid Identification of Acinetobacter baumannii Membrane Proteins and Polymyxin B's Effects. Front Cell Infect Microbiol. 2021 Sep 21;11:734578. doi: 10.3389/fcimb. 2021.734578. PMID: 34621692; PMCID: PMC8490878 (IF= 5.293)

7. Xue Li#, Lang Sun, Congran Li, Xinyi Yang, Xiukun Wang, Xinxin Hu, Tongying Nie, Youwen Zhang*, and Xuefu You*. The Attenuated Protective Effect of Outer Membrane Vesicles Produced by a mcr-1 Positive Strain on Colistin Sensitive Escherichia coli, Front Cell Infect Microbiol. 2021, 11: 701625 (IF=5.293)

8. Limin Dong#, Jing Pang, Xiukun Wang, Youwen Zhang, Guoqing Li, Xinxin Hu, Xinyi Yang, Chung-Dar Lu, Congran Li*,and Xuefu You*. Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1. Virulence. 2020,11(1): 57-67, DOI: 10.1080/21505594.2019.1708052 (IF=5.542)

9. Genzhu Wang#, Liang Li#, Xiukun Wang, Xue Li, Youwen Zhang, Jie Yu, Jiandong Jiang, Xuefu You*, and Yan Q Xiong*. Hypericin enhances β-lactam antibiotics activity through inhibition of sarA inMethicillin-Resistant Staphylococcus aureus. Acta Pharm Sin B. 2019;9(6):1174-1182. doi: 10.1016/j.apsb.2019.05.002 (IF=7.097)

10. Qing Wang#, Yuemeng Lv#, Jing Pang, Xue Li, Xi Lu, Xiukun Wang, Xinxin Hu, Tongying Nie, Xinyi Yang, Yan Q. Xiong, Jiandong Jiang, Congran Li*, and Xuefu You*. In vitro and in vivo Activity of D-Ser in Combination with β-lactam Antibiotics against Methicillin- Resistant Staphylococcus aureus. Acta Pharm Sin B. 2019;9(3): 496-504. doi: 10.1016/j.apsb.2019.01.017 (IF=7.097)