高小攀，研究員，現(xiàn)任中國醫(yī)學(xué)科學(xué)院&北京協(xié)和醫(yī)學(xué)院助理教授、中國醫(yī)學(xué)科學(xué)院病原生物學(xué)研究所課題組長。博士/碩士研究生導(dǎo)師。主持承擔(dān)國家科技重大專項(xiàng)課題1項(xiàng)，國家自然科學(xué)基金3項(xiàng)、北京市自然基金2項(xiàng)、以第一作者和通訊作者在Nature (2024) ,Molecular Cell (2025), Nature Communications (2021, 2022, 2024), Cell Discovery (2024), Cell Reports (2022, 2024), Protein & Cell (2022)等期刊上發(fā)表SCI近30篇。授權(quán)發(fā)明專利5項(xiàng)。兼任中國畜牧獸醫(yī)學(xué)會(huì)獸醫(yī)公共衛(wèi)生分會(huì)第四屆理事會(huì)理事，中華醫(yī)學(xué)會(huì)結(jié)核病學(xué)分會(huì)第十八屆委員會(huì)科技創(chuàng)新轉(zhuǎn)化專業(yè)委員會(huì)委員。
長期從事主要從事細(xì)胞保守的抗病毒免疫機(jī)制及其應(yīng)用。圍繞病原入侵和宿主抗病毒免疫的共性機(jī)制及其潛在應(yīng)用，開展了系列研究工作。研究結(jié)果為新型基因編輯，基因檢測以及基于藥物研發(fā)提供思路。
1.Gao X#，*, Zhu K#, Zhang W#, Wang L#, Wang L, Hua L, Niu T, Qin B, Yu X*, Zhu H*, Cui S*. RNA anti-CRISPRs deplete Cas proteins to inhibit the CRISPR-Cas system. Mol Cell. 2025 Dec 30: S1097-2765(25)00979-7. (SCIE)
2.Gao X#, Shang K#, Zhu K#, Wang L#, Mu Z#, Fu X, Yu X, Qin B, Zhu H*, Ding W*, Cui S*. Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature. 2024 Jan;625(7996):822-831. (SCIE)
3.Gao X#，*, Zhu K#, Wang L#, Shang K, Hua L, Qin B, Zhu H*, Ding W*, Cui S*. Structural basis for the interaction between human coronavirus HKU1 spike receptor binding domain and its receptor TMPRSS2. Cell Discov. 2024 Aug 8;10(1):84. (SCIE)
4.Gao X#, Wang B#, Zhu K#, Wang L#, Qin B, Shang K, Ding W*, Wang J*, Cui S*. The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction. Nat Commun. 2024 May 16;15(1):4176. (SCIE)
5.Zhu K#, Song L#, Wang L#, Hua L#, Luo Z, Wang T, Qin B, Yuan S, Gao X*, Mi W*, Cui S*. SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites. Acta Pharm Sin B. 2024 Sep;14(9):4164-4173. (SCIE)
6.Gao X#, Tian H#, Zhu K#, Li Q, Hao W, Wang L, Qin B, Deng H*, Cui S*. Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport. Nat Commun. 2022 Aug 15;13(1):4782. (SCIE)
7.Zhang C#, Yang F#, Wojdyla JA, Qin B, Zhang W, Zheng M, Cao W, Wang M, Gao X*, Zheng H*, Cui S*. An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein. Cell Rep. 2022 Jul 5;40(1):111030. (SCIE)
8.Yuan S#, *, Gao X#, Tang K#, Cai JP#, Hu M, Luo P, Wen L, Ye ZW, Luo C, Tsang JO, Chan CC, Huang Y, Cao J, Liang R, Qin Z, Qin B, Yin F, Chu H, Jin DY, Sun R, Chan JF*, Cui S*, Yuen KY*. Targeting papain-like protease for broad-spectrum coronavirus inhibition. Protein Cell. 2022 Dec;13(12):940-953. (SCIE)
9.Gao X#, Qin B#, Chen P#, Zhu K, Hou P, Wojdyla JA, Wang M, Cui S*. Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B. 2021 Jan;11(1):237-245. (C100), (SCIE)
10.Gao X#, Zhu K#, Qin B#, Olieric V, Wang M, Cui S*. Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions. Nat Commun. 2021 May 14;12(1):2843. (SCIE)
