雷曉波，研究員，博士研究生導師。2006年在中國科學院動物研究所獲得博士學位，主要從事細胞凋亡的分子機制研究。2006年進入中國醫(yī)學科學院病原生物學研究所工作升為助理研究員，2012年聘為副研究員，2018年聘為研究員。目前擔任中國微生物學會病毒學專業(yè)委員會委員和中華預防醫(yī)學會醫(yī)學病毒學分會青年小組委員。兩次入選全球前2%頂尖科學家榜單。

主要從事冠狀病毒和腸道病毒的基礎研究，聚焦重大和新發(fā)突發(fā)傳染病病毒的入侵、復制及與宿主相互作用的研究。系統(tǒng)揭示重要呼吸道病毒感染中宿主天然免疫應答與病毒免疫逃逸的博弈規(guī)律，發(fā)現(xiàn)多個影響病毒入侵、復制的關鍵宿主因子。承擔國家科技重大專項和國自然等多項課題，在Nat Commun、STTT和Cell Rep等SCI收錄雜志上發(fā)表SCI論文30余篇，9篇他引大于100，總被引用7100余次，H指數(shù)30（Research Gate）。研究成果入選 2020年Springer Nature中國學者年度高影響力研究。

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1.Chen YJ#, Shi YJ#, Zuo XY, Dong XJ, Xiao X, Chen L, Xiang ZC, Ren LL, Zhou Z, Wei WS*, Lei XB*, and Wang JW*. UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation. J Virol. 2025 Jul 22; 99(7): e0074125.

2.Ma RY#, Zhang XY#, Li RN, Dong XJ, Wang WJ, Jiang Q, Xiao X, Shi YJ, Chen L, Zheng T, Xiang ZC, Lei XB*, and Wang JW*. PLSCR1 suppresses SARS-CoV-2 infection by downregulating cell surface ACE2. J Virol. 2025 Mar 18; 99(3): e0208524.

3.Wang XH#, Hu ZL#, Zhang W#, Wu SW, Hao YJ, Xiao Xia, Li JJ, Yu XL, Yang CK, Wang JF, Zhang HY, Ma F, Shi WF, Wang JW, Lei XB*, Zhang XH*, and He SD*. Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16. J Cell Biol. 2023 Dec 4; 222(12): e202303108.

4.Zhang D#, Qiao LL#, Lei XB#, Dong XJ, Tong YG, Wang JW*, Wang ZY*, and Zhou RH*. Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein. Nat Commun. 2023 Jun 22; 14(1):3715.

5.Wu ZC#, Lei XB#, Wang X#, Zhang ZY, Li YM, Gao LF, Liang XH, Wang PH, Wang JW*, and Ma CH*. Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection. Signal Transduct Target Ther. 2023 Jan 18;8(1):19.

6.Guo SS#, Lei XB#, Chan Y#, Zhao JY#, Wang J#, Dong XJ, Liu Q, Zhang ZX, Wang LD, Yi DR, Ma L, Li QJ, Zhang YX, Ding JW, Liang C, Li XY, Guo F*, Wang JW*, and Cen S*. SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis. Signal Transduct Target Ther. 2022 Dec 27;7(1):400.

7.Zhou Z#, Zhang XY#, Lei XB#, Xiao X#, Jiao T, Ma RY, Dong XJ, Jiang Q, Wang WJ, Shi YJ, Zheng T, Rao J, Xiang ZC, Ren LL, Deng T, Jiang ZF, Dou ZX, and Wei WX*, and Wang JW*. Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection. Signal Transduct Target Ther. 2021 Nov 3; 6(1):382.

8.Wang WJ#, Zhou Z#, Xiao X#, Tian ZQ, Dong XJ, Wang CH, Li L, Ren LL, Lei XB*, Xiang ZC*, and Wang JW*. SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation. Cell Mol Immunol. 2021 Apr; 18(4):945-953. (C100)

9.Lei XB#, Dong XJ#, Ma RY#, Wang WJ, Xiao X, Tian ZQ, Wang CH, Wang Y, Li L, Ren LL, Guo F, Zhao ZD, Zhou Z*, Xiang ZC*, and Wang JW*. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun. 2020 Jul 30; 11(1): 3810. (ESI, C100)

10.Ou XY#, Liu Y#, Lei XB#, Li P, Mi D, Ren LL, Guo L, Guo RX, Chen T, Hu JX, Xiang ZC, Mu ZX, Chen X, Chen JY, Hu KP, Jin Q*, Wang JW*, and Qian ZH*. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun. 2020 Mar 27; 11(1):1620. (ESI, C100)