趙瑜，助理教授、研究員、博士生導(dǎo)師。2006年7月獲得青島大學(xué)醫(yī)學(xué)院生物技術(shù)專業(yè)學(xué)士學(xué)位，2012年7月獲得南開(kāi)大學(xué)生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)專業(yè)博士學(xué)位。作為第一完成人，獲全國(guó)顛覆性技術(shù)創(chuàng)新大賽優(yōu)秀獎(jiǎng)1項(xiàng)，中國(guó)健康長(zhǎng)壽創(chuàng)新大賽三等獎(jiǎng)1項(xiàng)。獲得美國(guó)生物醫(yī)學(xué)Kendall C. Edward獎(jiǎng)學(xué)金1項(xiàng)，遼寧省科技進(jìn)步一等獎(jiǎng)。獲得天津市杰出青年科學(xué)基金、天津市重點(diǎn)項(xiàng)目等資助。 院校引進(jìn)人才，2021年加入院校，曾在2012年7月進(jìn)入梅奧醫(yī)院攻讀博士后，并于2017年7月任梅奧醫(yī)院研究助理，2018年5月至2021年2月任梅奧醫(yī)院助理教授。

長(zhǎng)期從事新型核藥和核藥新靶點(diǎn)研究，提出核藥靶點(diǎn)研發(fā)不同于傳統(tǒng)藥物的“司機(jī)-乘客蛋白互換”新理論和核藥-免疫聯(lián)合治療新策略；創(chuàng)立核藥高效入核新技術(shù)，節(jié)省核素、降低核藥使用成本2倍以上，解決核藥診療貴的難題。承擔(dān)天津市杰青項(xiàng)目等5項(xiàng)國(guó)家和省部級(jí)科研課題，在Nature Medicine等雜志發(fā)表論文50余篇，H指數(shù)29，2篇被引次數(shù)破200，4篇被引破100，3篇被國(guó)際專利引用，進(jìn)入臨床研究。主編國(guó)際專著章節(jié)2部，參編1部。培養(yǎng)博士、碩士、博士后10余名，研究生獲國(guó)家獎(jiǎng)學(xué)金2人。

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     1. Shao C#, Zhang Y#, Li H#, Chen J#, Huang T, Li J, Wen S, Wang S, Fan S, Zhao Y*. Radiotherapy-resistant prostate cancer cells escape immune checkpoint blockade through the senescence-related ataxia telangiectasia and Rad3-related protein. Cancer Commun (Lond). 2024 Dec 19. doi: 10.1002/cac2.12636.

2. Wen S#, Wei Y#, Zen C, Xiong W, Niu Y, Zhao Y*. Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine. Molecular Cancer. 2020 Dec 12;19(1):171. (C100)

3. Zhang P.#, Wang D.#, Zhao Y.#, Ren S.#, Gao K.#, Ye Z., Wang S., Pan C.W., Zhu Y., Yan Y., Yang Y., Wu D., He Y., Zhang J., Lu D., Liu X., Yu L., Zhao S., Li Y., Lin D., Wang Y., Wang L., Chen Y., Sun Y.*, Wang C.*, Huang H.*, Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation, Nature Medicine, 23 (2017) 1055-1062. (C100)

4. Zhao Y#, Ding L#, Wang D, Ye Z, He Y, Ma L, Zhu R, Pan Y, Wu Q, Pang K, Hou X, Weroha SJ, Han C, Coleman R, Coleman I, Karnes RJ, Zhang J, Nelson PS, Wang L#, Huang H#. EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis. EMBO J. 2019 Mar 1;38(5):e99599. (C100)

5. Zhao Y, Wang L, Ren S, Wang L, Blackburn PR, McNulty MS, Gao X, Qiao M, Vessella RL, Kohli M, Zhang J, Karnes RJ, Tindall DJ, Kim Y, MacLeod R, Ekker SC, Kang T, Sun Y#, Huang H*. Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer. Cell Rep. 2016 Apr 19;15(3):599-610. (C100)

6. Huang Y, Li J, Wang S, Tian H*, Fan S*, Zhao Y*. Diselenide-based nanoparticles enhancing the radioprotection to the small intestine of mice. J Nanobiotechnology. 2025 Mar 22;23(1):236. doi: 10.1186/s12951-025-03276-3.

7. Yue T, Dong Y, Huo Q, Li W, Wang X, Zhang S, Fan H, Wu X, He X, Zhao Y*, Li D*. Nicotinamide riboside alleviates ionizing radiation-induced intestinal senescence by alleviating oxidative damage and regulating intestinal metabolism. J Adv Res. 2025 Jun;72:421-432.

8. Li W, Wang X, Dong Y, Huo Q, Yue T, Wu X, Lu L, Zhang J, Zhao Y*, Dong H*, Li D*. Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation-induced premature aging mice. Aging Cell. 2023 Nov;22(11):e13976.

9. Li H#, Zhao S, Jiang M, Zhu T, Liu J, Feng G, Lu L, Dong J, Wu X, Chen X, Zhao Y*, Fan S*. Biomodified Extracellular Vesicles Remodel the Intestinal Microenvironment to Overcome Radiation Enteritis. ACS Nano. 2023 Jul 25;17(14):14079-14098.

10. Dai D#, Yu J#, Huang T#, Li Y, Wang Z, Yang S, Li S, Li Y, Gou W, Li D, Hou W, Fan S*, Li Y*, Zhao Y*. PET imaging of new target CDK19 in prostate cancer. Eur J Nucl Med Mol Imaging. 2023 Jun 6.