呂家迪，準聘助理教授，副研究員，博士研究生導(dǎo)師。曾獲北京市科學(xué)技術(shù)獎自然科學(xué)獎一等獎、中國免疫學(xué)會青年學(xué)者獎，入選中國科協(xié)青年人才托舉工程。獲得國家自然科學(xué)基金優(yōu)秀青年基金項目、國家自然科學(xué)基金原創(chuàng)探索計劃項目、國家自然科學(xué)基金面上項目等項目資助。

長期從事生物機械力學(xué)與腫瘤免疫的研究；利用生物機械力學(xué)原理，針對腫瘤細胞休眠、干性的物理特征以及免疫逃逸等方面，做出了系列創(chuàng)新性、可持續(xù)性的研究工作，發(fā)現(xiàn)物理的軟度是腫瘤干細胞獨特的標志，先后闡明了免疫因子和細胞外基質(zhì)硬度參與調(diào)控腫瘤干細胞休眠的機制，并揭示生物機械力驅(qū)動的表觀遺傳修飾調(diào)控原始腫瘤細胞形成差異免疫原性的過程。

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1.Lv J#, Si T#, Wang D#, Zhang C, Zhou Y, Yu J, Jiang Y, Wu D, Zhou L, Wang Z, Zhou N, Chen J, Wei K, Zhang H, Ma J, Tang K, Cao X,Huang B*. Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells. Immunity. 2025 Aug 5:S1074-7613(25)00327-9 (IF=26.3)

2.Lv, J#, Zhou, Y.#, Zhou, N., Wang, Z., Chen, J., Zhang, Y., Zhang, H. & Huang, B*. Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Sci. Transl. Med. 15, eabq6024 (IF=17.1)

3.Lv J#, Liu Y.#, Mo S.#, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B*. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol.2022 Mar;24:364-72. (IF=11.0)

4.Lv, J#, Liu, Y.#, Cheng, F.#, Li, J., Zhou, Y., Zhang, H., Xie, J., Fang, Y., Zhang, H., Wang, N., Liu, Y. & Huang, B*. Cell softness regulates tumorigenicity and stemness of cancer cells. EMBO J. 40, e106123 (IF=28.2)

5.Lv, J#, Liu, X.#, Zhou, Y.#, Cheng, F., Chen, H., Zhou, N., Chen, J. & Huang, B*. YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation. Research 6, 0215  (IF=22.0)

6.Lv, J#, Wang, Z.#, Qu, Y.#, Zhu, H., Zhu, Q., Tong, W., Liu, J., Liu, Y., Qin, C*. & Huang, B*. Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages. Cell Discov. 7, 24 (IF=38.1)

7.Lv, J#, Yu, P.#, Wang, Z., Deng, W., Bao, L., Tong, W. M., Liu, Y., Qin, C. * & Huang, B*. ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques. Cell Mol. Immunol. 18, 1308-1310 (IF=22.0)

8.Wang, Z.#, Lv, J.#, Yu, P., Qu, Y., Zhou, Y., Liu, J., Tong, W. M., Qin, C. * & Huang, B*. SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages. Cell Mol. Immunol. 19, 210-221 (IF=14.0)

9.Liu, Y.#, Lv, J.#, Liu, J., Li, M., Xie, J., Qin, C., Tong, W. M. & Huang, B*. Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19. Cell Res. 30, 1078-1087 (IF=25.6).

10.Liu, Y.#, Lv, J.#, Liu, J.#, Liang, X., Jin, X., Zhang, H., Hu, Z. W., Cao, X., Qin, F. X. & Huang, B. * STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J. Clin. Invest. 128, 1057-1073 (IF=13.3)