劉玉英，1978年生，籍貫山東榮成，腫瘤免疫學(xué)家，中國(guó)醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所研究員，博士生導(dǎo)師。先后師從于軍事醫(yī)學(xué)科學(xué)院吳祖澤院士與中國(guó)醫(yī)學(xué)科學(xué)院藥物研究所胡卓偉教授，從事分子免疫和腫瘤藥理學(xué)研究。博士畢業(yè)后，在美國(guó)南卡羅來納州醫(yī)科大學(xué)進(jìn)行六年博士后研究，主要從事腫瘤生物學(xué)方面研究。2014年回國(guó)后，加入中國(guó)醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所，2022年升為助理研究員。

腫瘤免疫、腫瘤免疫治療、生物機(jī)械力腫瘤免疫、腫瘤休眠。

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1. Lv J#, Liu Y#, Mo S#, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B*. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol. 2022;24(3):364-372. (IF=22.198)

2. Liu Y#, Zhou N#, Zhou L#, Wang J, Zhou Y, Zhang T, Fang Y, Deng J, Gao Y, Liang X, Lv J, Wang Z, Xie J, Xue Y, Zhang H, Ma J, Tang K, Fang Y, Cheng F, Zhang C, Dong B, Zhao Y, Yuan P, Gao Q, Zhang H, Xiao-Feng Qin F, Huang B*. IL-2 regulates tumor-reactive CD8 + T cell exhaustion by activating the aryl hydrocarbon receptor. Nat Immunol. 2021;22(3):358-369. (IF=23.205)

3. Lv J#, Liu Y#, Cheng F#, Li J, Zhou Y, Zhang T, Zhou N, Li C, Wang Z, Ma L, Liu M, Zhu Q, Liu X, Tang K, Ma J, Zhang H, Xie J, Fang Y, Zhang H, Wang N, Liu Y* and Huang B*. Cell softness regulates tumorigenicity and stemness of cancer cells. EMBO J. 2021;40(2):e106123. (IF=10.905)

4. Liu Y*#, Zhang T#, Zhang H#, Li J, Zhou N, Fiskesund R, Chen J, Lv J, Ma J, Zhang H, Tang K, Cheng F, Zhou Y, Zhang X, Wang N and Huang B*. Cell Softness Prevents Cytolytic T-cell Killing of Tumor-Repopulating Cells. Cancer Res. 2021;81(2):476-488. (IF=10.269, ESI, F1000)

5. Liu Y#, Lv J#, Liu J, Li M, Xie J, Lv Q, Deng W, Zhou N, Zhou Y, Song J, Wang P, Qin C, Tong WM, Huang B*. Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19. Cell Res. 2020;30(12):1078-1087. (IF=17.916)

6. Gao Y#, Zhang H#, Zhou N#, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, Tang K, Ma J, Zhang H, Xie J, Yao F, Tong W, Liu Y*, Wang X*, Huang B*. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 2020;4(7):743-753. (IF=18.044)

7. Liu Y#, Fang Y#, Chen X#, Wang Z, Liang X, Zhang T, Liu M, Zhou N, Lv J, Tang K, Xie J, Gao Y, Cheng F, Zhou Y, Zhang Z, Hu Y, Zhang X, Gao Q, Zhang Y, Huang B*. Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci Immunol. 2020;5(43):eaax7969. (IF=11.996, C100)

8. Liu Y#, Liang X#, Dong W#, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Xiao-Feng Qin F, Huang B*. Tumor-Repopulating Cells Induce PD-1 Expression in CD8⁺ T Cells by Transferring Kynurenine and AhR Activation. Cancer Cell. 2018;33(3):480-494.e7. (IF=24.400, F1000, C100)

9. Liu Y#, Lv J#, Liu J#, Liang X, Jin X, Xie J, Zhang L, Chen D, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Jia Q, Zhu B, Kong Y, Guo J, Zhang H, Hu ZW, Cao X, Qin FX, Huang B*. STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J Clin Invest. 2018;128(3):1057-1073. (IF=12.87)

10. Liu Y#, Lv J#, Liang X#, Yin X, Zhang L, Chen D, Jin X, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Xie J, Wang N, Huang B*. Cancer Res. 2018;78(14):3926-3937. (IF=8.936)