石楊，研究員、助理教授、博士/碩士導(dǎo)師，美國華盛頓圣路易斯大學(xué)博士、博士后。長期深耕阿爾茲海默癥研究，研究發(fā)表在Nature, Neuron, JEM等期刊，多篇ESI高被引、F1000推薦論文，總引用4700余次。獲得美國 Rainwater 基金會tau研究領(lǐng)導(dǎo)力獎；美國神經(jīng)化學(xué)學(xué)會Marian Kies獎；華盛頓大學(xué)生物醫(yī)學(xué)研究獎、神經(jīng)系Tom Thach獎等學(xué)術(shù)獎項?；貒螳@得國家自然科學(xué)基金優(yōu)秀青年科學(xué)基金項目（海外）項目資助，獲得“北京市優(yōu)秀青年人才”稱號。

長期從事APOE-脂質(zhì)代謝-免疫軸調(diào)控AD發(fā)病機(jī)制與創(chuàng)新療法的研究。發(fā)現(xiàn)AD最大風(fēng)險基因APOE對tau病理生成及tau介導(dǎo)的神經(jīng)退行的直接調(diào)控作用 ；發(fā)現(xiàn)小膠質(zhì)細(xì)胞是驅(qū)動tau病理生成及神經(jīng)退行的根本動力；而APOE通過調(diào)節(jié)小膠代謝調(diào)控其激活，進(jìn)而調(diào)控AD疾病進(jìn)展。研究重新定義了AD發(fā)生發(fā)展的機(jī)制及APOE對AD的調(diào)控機(jī)制，推動APOE介導(dǎo)的脂質(zhì)代謝及神經(jīng)免疫成為AD機(jī)制研究與靶向治療的新焦點(diǎn)。

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1. Yang Shi#, Prabhakar Sairam Andhey, Christina Ising, Kairuo Wang, Lisa L Snipes, Kevin Boyer, Stephanie Lawson, Kaoru Yamada, Wei Qin, Melissa Manis, Javier Remolina Serrano, Bruno A Benitez, Robert E Schmidt, Maxim Artyomov, Jason D Ulrich, David M Holtzman*. Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms. Neuron 109 (15): 2413-2426. (IF=15.4, F1000, C100)

2. Yang Shi#, Melissa Manis, Justin Long, Kairuo Wang, Patrick M Sullivan, Javier Remolina Serrano, Rosa Hoyle, David M Holtzman*. Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. J Exp Med 216 (11): 2546-2561. (IF=10.6, ESI, C100)

3. Yang Shi# & David M Holtzman*. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nat Rev Immunol 18(12):759-772. (IF=60.9, ESI, C100)

4. Yang Shi#, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg , Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L Del-Aguila, John C Morris, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Anne M Fagan, Bruce L Miller, Adam L Boxer, William W Seeley , Oleg Butovsky , Ben A Barres, Steven M Paul, David M Holtzman*. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature 549(7673):523-527 (IF=48.5, F1000, ESI, C100)