冷泠，研究員，博士生導(dǎo)師，轉(zhuǎn)化醫(yī)學(xué)國家重大科技基礎(chǔ)設(shè)施獨(dú)立PI，疑難重癥及罕見病全國重點(diǎn)實(shí)驗(yàn)室獨(dú)立PI。作為第一完成人，曾獲日內(nèi)瓦國際發(fā)明展金獎、北京市科學(xué)技術(shù)獎-杰出青年中關(guān)村獎、中國發(fā)明協(xié)會發(fā)明創(chuàng)業(yè)獎人物獎和創(chuàng)新創(chuàng)業(yè)二等獎等。入選2023年度“長江學(xué)者獎勵計(jì)劃”青年學(xué)者國家高層次人才計(jì)劃。獲得國家自然科學(xué)基金、國家重點(diǎn)研發(fā)計(jì)劃、北京市科技計(jì)劃、軍委重點(diǎn)研發(fā)專項(xiàng)、中央高水平醫(yī)院臨床研究重點(diǎn)項(xiàng)目等資助。院校引進(jìn)人才。

長期從事復(fù)雜類器官構(gòu)建與疾病應(yīng)用的研究。創(chuàng)建空間基質(zhì)組學(xué)技術(shù)，揭示ECM調(diào)控干細(xì)胞命運(yùn)和類器官重建；創(chuàng)建多種近似生理組織的類器官模型及其在疾病機(jī)制、組織修復(fù)和藥物研發(fā)應(yīng)用的技術(shù)體系，提供疑難重癥罕見性重大疾病干預(yù)策略。以通訊作者身份在Nature子刊、Cell子刊等發(fā)表多篇研究性論著，8篇受邀雜志封面、F1000Prime亮點(diǎn)推薦等。培養(yǎng)本碩博和博后40余名，多人在NEJM等發(fā)表文章，獲國家獎學(xué)金和國家級課題。

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1. Ying Wang#, Yujie Wang#, Yao Yang, Ling Leng*. Prodrug nanosystem equipped with a sonosensitizer for combined chemotherapy and sonodynamic therapy of melanoma. Mater Today Bio, 2025, Aug 30:34:102262. (IF=10.2, F1000)

2. Jun Li#, Jie Ma#, Ruiyuan Cao#, Qiyu Zhang#, Mansheng Li#, Wenwen Wang, Yujie Wang, Wei Li, Yunping Zhu, Ling Leng*. A skin organoid-based infection platform identifies an inhibitor specific for HFMD. Nat Commun. 2025, Mar 13;16(1):2513. (IF=15.7)

3. Qiyu Zhang#, Jie Ma#, Jia Zhou#, Hanlin Zhang#, Mansheng Li#, Huizi Gong, Yujie Wang, Heyi Zheng, Jun Li*, Ling Leng*. A Study on the Inflammatory Response of the Brain in Neurosyphilis. Adv Sci. 2024, Nov 22;12(5):2406971 (IF=14.1)

4. Wenwen Wang#, Pu Liu#, Wendi Zhu#, Tianwei Li, Ying Wang, Yujie Wang, Jun Li, Jie Ma*, Ling Leng*. Skin organoid transplantation promotes tissue repair with scarless in frostbite. Protein Cell, 2024, Oct 4:pwae055 (IF=12.8)

5. Wendi Zhu#, Yue Wu#, Xiao Li#, Hongjun Yang, Fuchu He, Jie Ma*, Junying Wei*, Ling Leng*. A stroke organoids-multiomics platform to study injury mechanism and drug response. Bioact Mater, 2024, Feb Volume 44, Pages 68-81 (IF=20.3)

6. Jun Li#*, Jie Ma#, MingJuan Liu#, Mansheng Li#, Ming Zhang#, Wenhao Yin#, Mengyin Wu#, Xiao Li, Qiyu Zhang, Hanlin Zhang, Heyi Zheng, Chenhui Mao, Jian Sun, Wenze Wang, Wei Lyu, Xueping Yue, Wenjia Weng, Juan Li, Fengxin Chen, Yunping Zhu*, Ling Leng*. Large-Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis. Adv Sci. 2024, Feb 21:e2307744. (IF=15.1)

7. Jun Li#*, Jie Ma#, Qiyu Zhang#, Huizi Gong, Dunqin Gao, Yujie Wang, Biyou Li, Heyi Zheng, Zhihong Wu, Yunping Zhu*, Ling Leng*. Spatially proteomic map shows that extracellular matrix regulates epidermal growth. Nat Commun. 2022, Jul 11;13(1):4012. (IF=17.7, F1000)

8. Ling Leng#*, Jie Ma#, PeiPei Zhang#, SiChi Xu#, Xiao Li#, Ye Jin#, Jun Cai, Rui Tang, Lei Zhao, ZhiCheng He, ManSheng Li, Hui Zhang, LiangRui Zhou, ZhiHong Wu, TianRan Li, YunPing Zhu, HaiBo Wu, YiFang Ping, XiaoHong Yao, ChuHong Zhu, HaiTao Guo, LeYong Tan, ZhiYong Liang*, XiuWu Bian*, ShuYang Zhang*. Spatial-region-resolved proteome map reveals mechanism of COVID-19-associated heart injury. Cell Reports. 2022, Jun 14;39(11):110955. (IF=10.0)

9. Jie Ma#, Wei Li#, Ruiyuan Cao#, Dunqin Gao#, Qiyu Zhang, Xiao Li, Biyou Liu, Luye Lv, Mansheng Li, Junyi Jiang, Yujie Wang, Zhihong Wu, Jun Li, Yunping Zhu, Wu zhong*, Shuyang Zhang*, Ling leng*. Application of an iPSC-derived organoid model for located scleroderma therapy. Adv Sci. 2022, May;9(16):e2106075. (IF=17.5)

10. Jie Ma#, Jia liu#, Dunqin Gao#, Xiao Li#, Qiyu Zhang, Luye Lv, Yujie Wang, Jun Li, Yunping Zhu, Zhihong Wu, Hengrui Hu, Yufeng Li, Longda Ma, Qian Liu, Zhihong Hu, Shuyang Zhang*, Yiwu Zhou*, Manli Wang*, Ling Leng*. Establishment of human pluripotent stem cell-derived skin organoids enabled pathophysiological model of SARS-CoV-2 infection, Adv Sci. 2021, Dec 31;e2104192. (IF=17.5)