張博，中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)院，臨床醫(yī)學(xué)研究所獨立PI，準(zhǔn)聘研究員/博士研究生導(dǎo)師。獲得國家優(yōu)秀青年科學(xué)基金（2024），北京市科技新星（2022），北京協(xié)和醫(yī)院中堅骨干人才（2025）等項目資助。博士畢業(yè)于北京大學(xué)（醫(yī)學(xué)部）藥學(xué)院，化學(xué)生物學(xué)專業(yè)，師從周德敏教授/張禮和院士，2016年入職北京協(xié)和醫(yī)院，醫(yī)學(xué)科學(xué)研究中心專職科研工作。

長期從事生物技術(shù)藥物研究工作，針對目前內(nèi)源性生物大分子在臨床成藥性不足的具體臨床問題，聚焦于生物大分子的精準(zhǔn)修飾和人工設(shè)計，以及工程化免疫細(xì)胞治療技術(shù)的基礎(chǔ)研究，探索將其應(yīng)用于免疫穩(wěn)態(tài)調(diào)控的新策略和新理論發(fā)現(xiàn)。共發(fā)表SCI論文40余篇，其中以第一或通訊作者發(fā)表于Nature BME, 風(fēng)濕病頂刊Annals of the Rhe Dis, Cell Chem Bio, STTT等國際權(quán)威期刊，申請國家發(fā)明專利13項。主持或作為科技骨干承擔(dān)10余項國家和省部級科研課題，包括國自然基金，重大新藥創(chuàng)制專項等。

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1.Shengjie Li#, Siyuan Yu#, Mengzhao Wang, Bo Zhang*, Yan Xu*, Synergistic potential of PD-1 blockade and IL-2 in cancer therapy via targeted bi-functional molecule design, Sci Bull (Beijing). 2025 Aug 11:S2095-9273(25)00809-6. (IF = 21.1)

2.Jiaqi Sun#, Lingfeng Guo#, Dezhong Ji#*, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang*, Demin Zhou*, Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased IL-2 PEGylates, Adv Sci (Weinh). 2025 May;12(18):e2414931. (IF = 14.9)

3.Bo Zhang#*, Jiaqi Sun#, Yeshuang Yuan#, Dezhong Ji#, Yeting Sun#, Yudong Liu, Shengjie Li, Xingxing Zhu, Xunyao Wu, Jin Hu, Qiu Xie, Ling Wu, Lulu Liu, Boyang Cheng, Yuanjie Zhang, Lingjuan Jiang, Lidan Zhao, Fei Yu, Wei Song, Min Wang, Yue Xu, Shiliang Ma, Yunyun Fe, Lihe Zhang, Demin Zhou*, Xuan Zhang*, Proximity-enabled covalent binding of IL-2 to IL-2Ra selectively activates regulatory T cells and suppresses autoimmunity, Signal Transduction and Targeted Therapy, 2023, 8(1)(28). (IF = 39.3)

4.Yeting Sun#, Yeshuang Yuan, Bo Zhang*, Xuan Zhang*, CARs: a new approach for the treatment of autoimmune diseases, Sci China Life Sci. 2023 Apr;66(4): 711-728. (IF = 9.1)

5.Bo Zhang#, Jiaqi Sun#, Yan Wang#, Dezhong Ji#, Yeshuang Yuan#, Shengjie Li,  Yeting Sun, Yingqin Hou, Pengchong Li, Lidan Zhao, Fei Yu, Wenxiao Ma, Boyang Cheng, Ling Wu, Jin Hu, Min Wang, Wei Song, Xiaogang Li, Hao Li,  Yunyun Fei, Hua Chen, Lihe Zhang, George C. Tsokos*, Demin Zhou*, Xuan Zhang*, Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells, Nature biomedical engineering, 2021, 5(11): 1288-1305. (IF = 25.671)

6.Bo Zhang#,, Yan Wang#,, Yeshuang Yuan#,, Jiaqi Sun, Lulu Liu, Dan Huang, Jin Hu, Min Wang, Shengjie Li, Wei Song, Hua Chen, Demin Zhou*, Xuan Zhang*, In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells, Annals of the Rheumatic Diseases, 2021, 80(2): 176-184. (IF = 19.103)

7.Bo Zhang#, Yan Wang#, Shenlong Huang#, Jiaqi Sun, Min Wang, Wenxiao Ma,  YanboYou, Ling Wu, Jin Hu, Wei Song, Xudong Liu, Shengjie Li, Hua Chen, Guisheng Zhang, Lihe Zhang, Demin Zhou*, Lingjun Li*, Xuan Zhang*, Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator, Cell Chemical biology, 2021, 28(1): 60-69. (IF = 8.116)

8.Yuanyang Guo#, Bo Zhang#, Luying Wang, Shenlong Huang, Shilei Wang, Yanbo You, Gongming Zhu, Anlian Zhu, Mingwei Geng, Lingjun Li*, An efficient and easily-accessible ligand for Cu(I)-catalyzed azide-alkyne cycloaddition bioconjugation, Chem Commun (Camb); 2020 Nov 19;56(92):14401-14403. (IF = 5.996)

9.Bo Zhang#, Qi Yang#, Jingxian Chen, Ling Wu, Tianzhuo Yao, Yiming Wu,  Lihe Zhang, Qing Xia, Demin Zhou*, CRISPRi-Manipulation of Genetic Code Expansion via RF1 for Reassignment of Amber Codon in Bacteria, Sci Rep. 2016 Jan 28:6:20000. (IF = 4.7)

10.Bo Zhang#, Huan Xu, Jingxian Chen, Yongxiang Zheng, Yiming Wu, Longlong Si, Ling Wu, Chuanling Zhang, Gang Xia, Lihe Zhang, Demin Zhou*, Development of next generation of therapeutic IFN-a2b via genetic code, Acta Biomaterialia, 2015, Jun(19): 100-111. (IF = 6.1)