葉子璐，研究員，博士生導(dǎo)師。2007 年考入華中科技大學(xué)生物技術(shù)專業(yè)。2011年在中國(guó)科學(xué)院生物物理研究所攻讀碩士學(xué)位。丹麥哥本哈根大學(xué)細(xì)胞與遺傳醫(yī)學(xué)博士。長(zhǎng)期致力于基于質(zhì)譜的前沿蛋白質(zhì)組學(xué)技術(shù)研究。曾獲得國(guó)家自然科學(xué)基金優(yōu)秀青年科學(xué)基金項(xiàng)目(海外)的資助。院校引進(jìn)人才，2023年加入院校。曾擔(dān)任人類蛋白質(zhì)組組織(HUPO)生物與疾病人類蛋白質(zhì)組計(jì)劃(B/D-HPP)委員會(huì)委員、中國(guó)生物化學(xué)與分子生物學(xué)會(huì)蛋白質(zhì)組學(xué)專業(yè)分會(huì)副秘書長(zhǎng)。

長(zhǎng)期從事基于質(zhì)譜技術(shù)的蛋白質(zhì)組學(xué)與糖組學(xué)方法學(xué)創(chuàng)新及多維組學(xué)研究，在單細(xì)胞及痕量蛋白質(zhì)組學(xué)、高通量定量分析和糖基化研究等方向取得系列原創(chuàng)性成果。近年來(lái)，團(tuán)隊(duì)開(kāi)發(fā)了Chip-Tip和One-Tip等高靈敏度、高通量單細(xì)胞蛋白質(zhì)組學(xué)方法，以及Glyco-DIA等糖蛋白質(zhì)組學(xué)技術(shù)，顯著提升了檢測(cè)深度和精確性。研究成果發(fā)表SCI論文30余篇，其中以第一作者或通訊作者發(fā)表13篇，發(fā)表于Cell、Nature Methods（x2）、Nature Biotechnology、Nature Communications等國(guó)際著名期刊。

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1.Sabatier P, Lechner M, Guzmán UH, Beusch CM, Zeng X, Wang L, Izaguirre F, Seth A, Gritsenko O, Rodin S, Grinnemo KH, Ye Z#, Olsen JV#. Global analysis of protein turnover dynamics in single cells. Cell. 2025. 188(9):2433. (IF = 42.5)

2.Ye Z#*, Sabatier P#, van der Hoeven L, Lechner MY, Phlairaharn T, Guzman UH, Liu Z, Huang H, Huang M, Li X, Hartlmayr D, Izaguirre F, Seth A, Joshi HJ, Rodin S, Grinnemo KH, H?rning OB, Bekker-Jensen DB, Bache N, Olsen JV*. Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics. Nature Methods, 2025: 1-11. (IF = 32.1)

3.Guzman UH#, Martinez-Val A#, Ye Z#, Damoc E, Arrey TN, Pashkova A, Renuse S, Denisov E, Petzoldt J, Peterson AC, Harking F, ?stergaard O, Rydbirk R, Aznar S, Stewart H, Xuan Y, Hermanson D, Horning S, Hock C, Makarov A, Zabrouskov V, Olsen JV*. Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition. Nature Biotechnology 2024,1-12. (IF = 41.7)

4.Ye Z#*, Sabatier P#, Martin-Gonzalez J, Eguchi A, Lechner M, ?stergaard O, Xie J, Guo Y, Schultz L, Truffer R, Bekker-Jensen DB, Bache N, Olsen JV*. One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes. Nature Communications 2024, 15(1): 2474. (IF = 15.7，ESI)

5.Ye Z#, Kilic G#, Dabelsteen S#, Marinova IN, Th?fner JFB, Levann AMR, Bagdonaite I, Vakhrushev S, Brakebusch CH, Olsen J* and Wandall H*. Loss of TGF-βRII signaling induces invasive tissue growth in a human organotypic skin model. Science Signaling 2022, 15(761). (IF = 7.3)

6.Ye Z#, Batth T, Rüther PL and Olsen J. A deeper look at carrier proteome effects for single-cell proteomics. (2022) Communications Biology, 10.1038/s42003-022-03095-4 (IF = 6.55)

7.Mao Y, Wang S, Zhao Y, Konstantinidi A, Sun L, Ye Z* and Vakhrushev SY*. Systematic Evaluation of Fragmentation Methods for Unlabeled and Isobaric Mass Tag-Labeled O-Glycopeptides. (2021) Anal Chem 93:11167-11175. (IF =8.01)

8.Ye Z# and Vakhrushev SY. The Role of Data-Independent Acquisition for Glycoproteomics. (2021) Mol Cell Proteomics 20:100042. (IF = 5.91)

9.Ye Z#, Mao Y, Clausen H and Vakhrushev SY. Glyco-DIA: a method for quantitative O-glycoproteomics with in silico-boosted glycopeptide libraries. (2019) Nat Methods 16:902-910. (IF = 30.82)

10.Zhang C#, Ye Z#, Xue P, Shu Q, Zhou Y, Ji Y, Fu Y, Wang J and Yang F. Evaluation of Different N-Glycopeptide Enrichment Methods for N-Glycosylation Sites Mapping in Mouse Brain. (2016) J Proteome Res 15:2960-8. (IF = 4.27)