單強(qiáng)，1983年生，系統(tǒng)醫(yī)學(xué)研究院研究員，博士生導(dǎo)師。2002年考入河南師范大學(xué)生物技術(shù)專(zhuān)業(yè)，2006年獲學(xué)士學(xué)位。2006-2013年在中科院北京基因組研究所生化與分子生物學(xué)專(zhuān)業(yè)碩博連讀。
      院校引進(jìn)人才，2022年加入院校。曾于2013-2022年先后在美國(guó)哈佛大學(xué)布列根和婦女醫(yī)院、愛(ài)荷華大學(xué)微生物和免疫學(xué)系、哈肯薩克子午線(xiàn)醫(yī)學(xué)院發(fā)現(xiàn)與創(chuàng)新中心以博士后、助理研究員身份進(jìn)行科研工作。主要研究CD8+ T細(xì)胞不同譜系的建立、維持機(jī)制。2022年加入系統(tǒng)醫(yī)學(xué)研究院，任職研究員。

解析Tcf1、Runx3和Tle3等記憶CD8+T細(xì)胞亞群命運(yùn)決定關(guān)鍵轉(zhuǎn)錄因子的新功能和作用機(jī)制，為優(yōu)化疫苗設(shè)計(jì)和免疫治療提供新的干預(yù)靶點(diǎn)，具有潛在臨床轉(zhuǎn)化價(jià)值。主要研究成果以第一或通訊作者身份發(fā)表在Nature Immunology (2017、2022a、2022b和2024) 、Nature Communications (2021) 、Cellular & Molecular Immunology (2021) 等專(zhuān)業(yè)期刊。相關(guān)研究成果被Faculty of 1000 推薦，并被Nature Reviews Immunology、Immunological Reviews、Trends in Immunology等高水平綜述雜志引用。目前主持國(guó)家級(jí)青年海外高層次人才項(xiàng)目、國(guó)家自然科學(xué)基金面上項(xiàng)目和醫(yī)科院創(chuàng)新工程項(xiàng)目等多項(xiàng)課題。

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1. Xin Zhao#, Wei Hu#, Sung Rye Park#, Shaoqi Zhu#, Sheng'en Hu, Chongzhi Zang, Weiqun Peng, Qiang Shan*, Hai-Hui Xue*. The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates. Nat Immunol. 2024 Feb;25(2):294-306. (IF: 27.6)

2. Qiang Shan#, Shaoqi Zhu#, Xia Chen, Jia Liu, Shuang Yuan, Xiang Li, Weiqun Peng*, Hai-Hui Xue*; Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8⁺ T cell homeostasis., Nat Immunol. 2022, 23(8):1222-1235. (IF: 25.6)

3. Qiang Shan#, Sheng'en Hu#, Xia Chen, Zhouhao Zeng, Shaoqi Zhu, Weiqun Peng*, Hai-Hui Xue*. Tcf1 preprograms glycolysis mobilization in central memory CD8⁺ T cells in recall response. Nat Immunol, 2022, 23(3): 386-398. (IF: 25.6)

4. Qiang Shan#, Xiang Li#, Xia Chen, Zhouhao Zeng, Shaoqi Zhu, Kexin Gai, Weiqun Peng*, Hai-Hui Xue*. Tcf1 and Lef1 provide constant supervision to mature CD8⁺ T cell identity and function by organizing genomic architecture. Nat Commun. 2021 ,12(1):5863 (IF: 14.9)

5. Qiang Shan#, Sheng'en Hu#, Xia Chen, Derek B Danahy, Vladimir P Badovinac, Chongzhi Zang*, Hai-Hui Xue*. Ectopic Tcf1 Expression Instills a Stem-Like Program in Exhausted CD8⁺ T Cells to Enhance Viral and Tumor Immunity. Cell Mol Immunol. 2021 ,18(5):1262-1277. (IF: 11.5)

6. Qiang Shan#, Zhouhao Zeng#, Shaojun Xing, Fengyin Li, Stacey M Hartwig, Jodi A Gullicksrud, Samarchith P Kurup, Natalija Van Braeckel-Budimir, Yao Su, Matthew D Martin, Steven M Varga, Ichiro Taniuchi, John T Harty, Weiqun Peng*, Vladimir P Badovinac, Hai-Hui Xue*. The transcription factor Runx3 guards cytotoxic CD8⁺ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017,18(8):931-939. (F1000) (IF: 21.8)