程輝，中國(guó)醫(yī)學(xué)科學(xué)院血液病醫(yī)院（血研所）研究員，協(xié)和準(zhǔn)長(zhǎng)聘助理教授，博導(dǎo)。2007年獲浙江大學(xué)學(xué)士學(xué)位。2013年獲北京協(xié)和醫(yī)學(xué)院博士學(xué)位。研究方向?yàn)樵煅杉?xì)胞及其微環(huán)境。以第一/通訊作者（含共同）在Nat Cell Biol、J Clin Invest、J Exp Med、Blood等雜志上發(fā)表論文和綜述20余篇。國(guó)家重點(diǎn)研發(fā)計(jì)劃首席科學(xué)家。獲國(guó)家優(yōu)青、天津市杰青等人才項(xiàng)目。獲國(guó)家自然科學(xué)獎(jiǎng)二等獎(jiǎng)。獲國(guó)內(nèi)外專利5項(xiàng)。中國(guó)生理學(xué)會(huì)青年委員和天津市血液與再生醫(yī)學(xué)學(xué)會(huì)理事。

作為最早被應(yīng)用于臨床的成體干細(xì)胞，造血干細(xì)胞（HSC）功能和分化模式一直以來(lái)是研究的熱點(diǎn)。我們實(shí)驗(yàn)室的研究目標(biāo)是明確HSC在穩(wěn)態(tài)和疾病狀態(tài)下的內(nèi)外調(diào)控機(jī)制，揭示微環(huán)境在其中的變化規(guī)律繼而對(duì)HSC的影響機(jī)理，探討HSC選擇性保護(hù)的分子機(jī)制，以期為白血病的治療提供新的思路和策略。

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1. Yang S.#, Sun G.#, Wu P.#, Chen C.#, Kuang Y., Liu L., Zheng Z., He Y., Gu Q., Lu T., Zhu C., Wang F., Gou F., Yang Z., Zhao X., Yuan S., Yang L., Lu S., Li Y., Lv X., Dong F., Ma Y., Yu J., Ng L., Shi L., Liu J.*, Shi L.*, Cheng T.*, Cheng H.*. WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation. J Exp Med. 2022; 219(4). (IF= 17.579)

2. Wang T.#, Xia C.#, Weng Q., Wang K., Dong Y., Hao S., Dong F., Liu X., Liu L., Geng Y., Guan Y., Du J., Cheng T., Cheng H.*, Wang J*. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica. 2022; 107(1). (IF=11.047)

3. Wang FJ.#, He J.#, Liu S.#, Gao A., Yang L., Sun G., Ding W., Li C., Wang F., Wang X., Zhu P., Hao S., Ma Y.*, Cheng H.*, Yu J.*, Cheng T*. Comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation. Blood. 2021;138(20). (IF=25.476)

4. Yuan S., Sun G., Zhang Y., Dong F., Cheng H.*, Cheng T*. Understanding the ‘SMART’ features of hematopoietic stem cells and beyond. Sci China Life Sci. 2021;64(12). (IF=10.372)

5. Huang D.#, Sun G.#, Hao X.#, He X.#, Zheng Z., Chen C., Yu Z., Xie L., Ma S., Liu L., Zhou B., Cheng H.*, Zheng J.*, and Cheng T*. ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression. J Clin Invest. 2021;131(1). (IF=19.456)

6. Zhang C.#, Xu Z.#, Yang S.#, Sun G.#, Jia L., Zheng Z., Gu Q., Tao W.*, Cheng T.*, Li C.* and Cheng H.*. tagHi-C reveals 3D chromatin architecture dynamics during hematopoiesis. Cell Rep. 2020;32(13). (IF=9.423)

7.   Dong F., Cheng H.*, Ema H.*, Cheng T*. Probing the fate of transplanted hematopoietic stem cells: is the combinational approach "FIT" for purpose? Sci China Life Sci. 2020;63(11):1755-8. (IF=6.037)

8.   Dong F.#, Hao S.#, Zhang S.#, Zhu C.#, Cheng H.#, et al. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis. Nat Cell Biol. 2020;22(6):630-9. (IF=28.824)

9.   Xia C.#, Wang T.#, Cheng H.#, et al. Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia. 2020;34(9):2375-83. (IF=11.528)

10. Ma S.#, Sun G.#, Yang S., Ju Z.*, Cheng T.*, Cheng H.*. Effects of telomere length on leukemogenesis. Sci China Life Sci. 2020;63(2):308-11. (IF=6.037)