董芳,博士,研究員,干細胞與再生醫(yī)學(xué)專業(yè)博士生導(dǎo)師。2014 年博士畢業(yè)于北京協(xié)和醫(yī)學(xué)院,同年加入中國醫(yī)學(xué)科學(xué)院血液病醫(yī)院(中國醫(yī)學(xué)科學(xué)院血液學(xué)研究所)從事科研工作。研究方向主要集中在造血干細胞生物學(xué)調(diào)控和轉(zhuǎn)化研究,承擔(dān)國家基金委優(yōu)秀青年科學(xué)基金、天津市杰出青年基金、國家重點研發(fā)計劃子課題負責(zé)人等項目資助,榮獲2022年度天津市自然科學(xué)特等獎(排名第4)。
長期從事造血干細胞生物學(xué)調(diào)控研究;擅長利用系列單細胞技術(shù)和方法揭示HSC在穩(wěn)態(tài)及應(yīng)激/疾病條件下的命運選擇、自我更新以及多向分化能力的改變。以第一作者和/或通訊作者在 Nat Cell Biol、Blood、J Clin Invest 等雜志發(fā)表 SCI 文章共計14篇。獲國家發(fā)明專利 2 項。參編中英文著作3部。培養(yǎng)博士/碩士研究生10名。
1. Fang Dong#, Sen Zhang#, Caiying Zhu#, Zining Yang#, Lisha Wang#, Yao Ma, Jiayi Lu, Xialin Li, Xiaofang Wang, Nini Wang, Shanshan Zhang, Miner Xie, Jinhong Wang, Xiaobing Zhang, Yawei Zheng, Shihui Ma, Hideo Ema, Hui Cheng, Sha Hao, Toshio Suda, Yu Lan, Bing Liu, Ping Zhu, Junren Chen, Tao Cheng. Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of "Super" transplantability. Blood. 2025 Jul 31;146(5):546-557.
2. Yaojin Huang#, Xiaowei Xie#, Mengyao Liu#, Yawen Zhang#, Junye Yang, Wenling Yang, Yu Hu, Saibing Qi, Yahui Feng, Guojun Liu, Shihong Lu, Xuemei Peng, Jinhui Ye, Shihui Ma, Jiali Sun, Lu Wang, Linping Hu, Lin Wang, Xiaofan Zhu, Hui Cheng, Zimin Sun, Junren Chen, Fang Dong*, Yingchi Zhang*, Tao Cheng*. Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline. J Clin Invest. 2025 Mar 4;135(9):e183607
3. Xiaowei Xie#, Fanglin Gou#, Zhaofeng Zheng, Yawen Zhang, Yingchi Zhang, Fang Dong*, Tao Cheng*, Hui Cheng*. Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth. iScience. 2024 Jul 3;27(8):110445.
4. Nini Wang#, Shangda Yang#, Yu Li, Fanglin Gou,Yanling Lv, XiangnanZhao, YifeiWang, Chang Xu, Bin Zhou, Fang Dong*, Zhenyu Ju*, Tao Cheng*, Hui Cheng*. p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells. Protein Cell. 2024 May 9:pwae022.
Fang Dong#; Sha Hao#; Sen Zhang#; Caiying Zhu#; Hui Cheng #; Zining Yang, Fiona K Hamey, Xiaofang Wang, Ai Gao, Fengjiao Wang, Yun Gao, Ji Dong, Chenchen Wang, Jinyong Wang, Yu Lan, Bing Liu, Hideo Ema, Fuchou Tang, Berthold Gottgens*, Ping Zhu*, Tao Cheng*, Differentiation of transplanted hematopoietic stem cells tracked by single cell transcriptomic analysis. Nat Cell Biol, 2020 22(6):630-639.