王璐，1985年生，血液學研究所研究員，博士生導師。2013年在中國科學院大學獲得細胞生物學專業(yè)博士學位，主要進行造血干細胞發(fā)育研究。2019年進入中國醫(yī)學科學院血液學研究所組建研究團隊，主要進行造血干細胞發(fā)育及疾病模型相關(guān)研究。

我們目前的研究從體內(nèi)發(fā)育、疾病模型和作用機制三個層次深入探討關(guān)鍵調(diào)控因子在血液系統(tǒng)發(fā)育和血液疾病發(fā)生的作用機理，構(gòu)建相關(guān)疾病模型，以期為相關(guān)疾病治療和藥物開發(fā)提供理論基礎(chǔ)。

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1. Li Y#, Tang C#, Liu F, Liu F, Zhu P*, Wang L*. DNA methylation safeguards endothelial-to-hematopoietic transition by repression of Notch signaling. Development. 2022 May 3;dev.200390. doi: 10.1242/dev.200390. (IF=6.862)

2. Lv P^#, Ma D^#, Gao S^#, Zhang Y, Bae YK, Liang G, Gao S, Choi JH, Kim CH, Wang L*, Liu F*. Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 2020 Sep 8;15(3):749-760. (IF=6.032)

3. Lu X, Zhang Y, Liu F*, and Wang L*. Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus During Zebrafish Embryogenesis. J Immunol. 2020, 204(9):2447-2454. (IF=5.422)

4. Liu ZB, Tu HQ, Kang YS, Xue YY, Ma DY, Zhao CT, Li HY, Wang L*, Liu F*. Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature Commun. 2019, 10(1):1839. (IF=11.878)

5. Yang Y^#, Wang L^#, Han X^#, Yang WL^#, Zhang M^#, Ma HL, Sun BF, Li A, Xia J, Chen J, Heng J, Wu B, Chen YS, Xu JW, Yang X, Yao H, Sun J, Lyu C, Wang HL, Huang Y, Sun YP, Zhao YL, Meng A, Ma J*, Liu F* and Yang YG*. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol Cell. 2019, 75(6):1188-1202. (IF=14.548)

6. Wang L^#, Liu ZB, Lin H, Ma DY, Tao QH, Liu F*. Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 2017, 36(20):2987-97. (IF=10.557)

7. Zhang CX^#, Chen YS^#, Sun BF^#, Wang L^#, Yang Y^#, Ma DY, Lv JH, Heng J, Ding YY, Xue YY, Lu XY, Xiao W, Yang YG*, Liu F*. m6A modulates haematopoietic stem and progenitor cell specification. Nature. 2017, 549(7671):273-76. (IF=40.137)

8. Lv JH^#, Wang L^#, Gao Y, Ding YQ, Liu F*. 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017, 214(2):529-545. (IF=10.790)

9. Wang L^#, Liu TH^#, Xu LJ^#, Gao Y, Wei YL, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong DL, Liu F*. Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 2013, 122(3):367-75. (IF=9.775; F1000)

10. Wang L, Zhang PP, Wei YL, Gao Y, Patient R, Liu F*. A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 2011, 118(15):4102-10. (IF=10.558; F1000)