楊柳柳，研究員，博士研究生導(dǎo)師。主持中國(guó)醫(yī)學(xué)科學(xué)院創(chuàng)新工程項(xiàng)目一項(xiàng)，國(guó)家自然科學(xué)基金優(yōu)秀青年科學(xué)基金（海外）一項(xiàng)，國(guó)家自然科學(xué)基金面上項(xiàng)目一項(xiàng)，天津市自然科學(xué)基金青年項(xiàng)目A類一項(xiàng)，作為課題負(fù)責(zé)人參與國(guó)家重點(diǎn)研發(fā)項(xiàng)目一項(xiàng)。 院校引進(jìn)人才，2024年加入院校。曾在美國(guó)康奈爾大學(xué)威爾醫(yī)學(xué)院從事博士后研究（2019年9月至2024年5月）。

長(zhǎng)期從事人多能干細(xì)胞來(lái)源的類器官的開(kāi)發(fā)及應(yīng)用等方面的研究。建立了人多能干細(xì)胞分化的三胚層多種組織細(xì)胞及類器官平臺(tái)，研究了病毒感染以及免疫細(xì)胞與組織細(xì)胞的互作，篩選出具有抗病毒和細(xì)胞保護(hù)作用的藥物。同時(shí)，解析了干細(xì)胞自我更新調(diào)控及免疫細(xì)胞譜系建立的分子機(jī)制。以第一作者（含共同）或通訊作者在 Nature、Cell Stem Cell、Nature Methods、Nature Immunology 等期刊發(fā)表論文17篇，其中高被引論文4篇，總引用次數(shù)超過(guò)3000次。

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1. Han Y*, Leng D, Zhang T, Ge J, Fang Y, Lu T, Dong X, Nair MS, de Silva N, Han Z, Jiao T, Huang Y, Zhao M, Saqi A, Hibshoosh H, Meng Z, Xiang JZ, Pan C, Sun Y, Ho DD, Evans T, Liu J, Yang L*, Que J*, Chen S*. A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection. Adv Sci (Weinh). 2025 Sep;12(36):e03932. doi: 10.1002/advs.202503932. Epub 2025 Jul 25. PMID: 40712141; PMCID: PMC12463091.

2. Yang L^#*, Han Y^#, Zhang T^#, Dong X, Ge J, Roy A, Zhu J, Lu T, Jeya Vandana J, de Silva N, Robertson CC, Xiang JZ, Pan C, Sun Y, Que J, Evans T, Liu C, Wang W, Naji A, Parker SCJ, Schwartz RE*, Chen S*. Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection. Cell Stem Cell. 2024 Nov 7;31(11):1612-1629.e8.

3. Yang L^#, Kim T. W^#, Han Y^#, Nair M. S^#, Harschnitz O^#, Zhu J^#, Wang P^#, Koo S.Y, Lacko L A, Chandar V, Bram Y, Zhang T, Zhang W, He F, Pan C, Wu J, Huang Y, Evans T, Valk P. v. d, Titulaer M. J, Spoor J. KH, Brien R.L. FO, Bugiani M, Berg W. DJ V d, Schwartz R. E*, Ho D. D*, Studer L*, Chen S*. SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell Stem Cell. 2024 Feb 1;31(2):196-211.e6.

4. Han Y^#, Tan L^#, Zhou T^#, Yang L^#, Carrau L^#, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D; NYSCF Global Stem Cell Array Team; Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T, Chen S*. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022 Oct 6;29(10):1475-1490.e6. doi: 10.1016/j.stem.2022.09.008. PMID: 36206731; PMCID: PMC9550219.

5. Han Y^#, Yang L^#, Lacko LA, Chen S*. Human organoid models to study SARS-CoV-2 infection. Nat Methods. 2022 Apr;19(4):418-428. doi: 10.1038/s41592-022-01453-y. Epub 2022 Apr 8. PMID: 35396481.

6. Yang L^#, Nilsson-Payant BE^#, Han Y^#, Jaffré F^#, Zhu J^#, Wang P, Zhang T, Redmond D, Houghton S, M?ller R, Hoagland D, Carrau L, Horiuchi S, Goff M, Lim JK, Bram Y, Richardson C, Chandar V, Borczuk A, Huang Y, Xiang J, Ho DD*, Schwartz RE*, tenOever BR*, Evans T*, Chen S*. Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem Cell Reports. 2021 Sep 14;16(9):2274-2288. doi: 10.1016/j.stemcr.2021.07.012. Epub 2021 Jul 20. Erratum in: Stem Cell Reports. 2021 Oct 12;16(10):2565. doi: 10.1016/j.stemcr.2021.09.008. PMID: 34403650; PMCID: PMC8289700.

7. Yang L^#, Han Y^#, Jaffré F^#, Nilsson-Payant BE^#, Bram Y, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Xiang J, Ho DD*, tenOever BR*, Schwartz RE*, Evans T*, Chen S*. An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circ Res. 2021 Jun 25;129(1):33-46.

8. Han, Y^#, Duan, X^#, Yang, L^#, Nilsson-Payant, B.E^#, Wang, P^#, Duan, F^#, Tang, X^#, Yaron, T.M^#, Zhang, T, Uhl, S, Bram Y, Richardson, C, Zhu, J, Zhao, Z, Redmond. D, Houghton, S, Nguyen, D.T, Xu, D, Wang, X, Jessurun, J, Borczuk, A, Huang, Y, Johnson, J.L, Liu, Y, Xiang, J, Wang, H*, Cantley, L.C*, tenOever, B.R*, Ho, D.D*, Pan, F*, Evans, T*, Chen, H.J*, Schwartz, R.E*, Chen, S*. Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids. Nature. 2021 Jan;589(7841):270-275. (C100)

9. Yang L^# , Han Y^#, Nilsson-Payant BE^#, Gupta V^#, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC*, Ho DD*, tenOever BR*, Evans T*, Schwartz RE*, Chen S*. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7. (C100)

10. Liu B^#, Ye B^#, Yang L^#, Zhu X^#, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R*, Tian Y*, Fan Z*. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat Immunol. 2017 May;18(5):499-508. doi: 10.1038/ni.3712. Epub 2017 Mar 20. PMID: 28319097. (C100)