王洪，研究員，博士研究生導(dǎo)師。獲國家高層次青年拔尖人才，國家高層次留學(xué)回國人才，天津市“杰青”、科技創(chuàng)新領(lǐng)軍人才等稱號。主持國家自然科學(xué)基金專項(xiàng)和面上等項(xiàng)目。研究成果獲2023年度中國血液學(xué)十大研究進(jìn)展；人類蛋白質(zhì)組學(xué)組織HUPO（領(lǐng)域最權(quán)威國際學(xué)會(huì)）2023年度亮點(diǎn)成果獎(jiǎng)‘Proteomics Highlight of Year’（亞洲唯一入圍并獲獎(jiǎng)）。 院校引進(jìn)人才，2021年加入院校。曾在美國圣裘德兒童研究醫(yī)院結(jié)構(gòu)生物系從事博士后研究，隨后在該院蛋白質(zhì)組學(xué)中心任研究員。

長期從事前沿組學(xué)技術(shù)開發(fā)和多組學(xué)驅(qū)動(dòng)的血液精準(zhǔn)醫(yī)學(xué)研究。以通訊/第一作者在Immunity、Cancer Cell、Nature Communications、PNAS、Molecular Neurodegeneration、Genome Biology等發(fā)表研究論文多篇；申請專利以及軟著6項(xiàng)，授權(quán)4項(xiàng)；實(shí)現(xiàn)成果轉(zhuǎn)化1項(xiàng)（50萬）；啟動(dòng)研究者發(fā)起的IIT臨床試驗(yàn)2項(xiàng)，成果相關(guān)新藥獲批IND并已進(jìn)入III期臨床試驗(yàn)。擔(dān)任亞太人類蛋白質(zhì)組協(xié)會(huì)（AOHUPO）委員、中國生物化學(xué)與分子生物學(xué)會(huì)蛋白質(zhì)組學(xué)分會(huì)委員、中國生理學(xué)會(huì)整合生理學(xué)專委會(huì)委員、天津市分析測試協(xié)會(huì)常務(wù)理事。

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1. Dandan Yang#, Tingting Zhang#, Yang Yang#, Dong Zhang, Zhiwei Zhou, Ning Wang, Jinting Fan, Chenghua Xu, Youyang Fang, Lichun Kang, Mingming Niu, Chunliang Li, Long Shen?, Hong Wang?. Integration of CRISPR-Cas9 screens and multi-omics profiling reveals chromodomain helicase DNA binding protein 7-angiopoietin-1 as a novel multidrug resistance axis in acute myeloid leukemia. Interdisciplinary Medicine. 2025. e70053. (IF:13.6)

2. Wenchang Qian#, Penglei Jiang#, Mingming Niu#, Yujuan Fu#, Deyu Huang, Dong Zhang, Ying Liang, Qiwei Wang, Yingli Han, Xin Zeng, Yixin Shi, Lingli Jiang, Zebin Yu, Jinxin Li, Huan Lu, Hong Wang*, Baohui Chen?, Pengxu Qian?. Selective identification of epigenetic regulators at methylated genomic sites by SelectID. Nature Communications. 2025.16(1): 3709. (IF: 15.7)

3. Mingming Niu#, Ning Wang#, Dandan Yang#, Lixia Fu#, Yang Yang, Long Shen, Hong Wang*, Xianfeng Shao?. Multi-omics integration reveals immune hallmarks and biomarkers associated with FLT3 inhibitor sensitivity in FLT3-mutated AML. Blood Science. 7(2):p e00227, June 2025. (IF: 2.7)

4. Hong Wang#?, Tao Cheng?. Towards a blood ecosystem approach to dissect systemic diseases. Sci China Life Sci. 2024. 67 (7), 1528-1531. (IF:9.5)

5. Hong Wang#?, Cuicui Liu#, Xiaowei Xie#, Mingming Niu#, Yingrui Wang#, Xuelian Cheng#, Biao Zhang#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma, Huijun Wang, Guoqing Zhu, Yang Lu, Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentiao Jiang, Ximo Wang?, Zhongyang Shen?, Tiannan Guo?, Jiaxi Zhou?, Ping Zhu?, Tao Cheng?. Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection. Immunity. 2023.56(6):1410-1428. (IF: 25.5)

6. Shaela Wright#, Jianzhong Hu#, Hong Wang#, Judith Hyle, Yang Zhang, Guoqing Du, Marina Y Konopleva, Steven M Kornblau, Mohamed Nadhir Djekidel, Wojciech Rosikiewicz, Beisi Xu, Rui Lu, Jun J Yang*, Chunliang Li*. Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens. Proc Natl Acad Sci USA. 2023. Apr 18;120(16):e2220134120. (IF: 9.4)

7. Hong Wang#*, Kaushik Kumar Dey#, Ping-Chung Chen, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Xusheng Wang, Bing Bai, Yun Jiao, Surendhar Reddy Chepyala, Vahram Haroutunian, Bin Zhang, Thomas G. Beach and Junmin Peng*. Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease. Molecular Neurodegeneration. 2020.15(1):43. (IF: 14.195, C100)

8. Hong Wang#, Alexander K Diaz, Timothy I Shaw, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Barbara S Paugh, Yang Zhang, Jeffrey Sifford, Bing Bai, Zhiping Wu, Haiyan Tan, Suiping Zhou, Laura D Hover, Heather S Tillman, Abbas Shirinifard, Suresh Thiagarajan, Andras Sablauer, Vishwajeeth Pagala, Anthony A High, Xusheng Wang, Chunliang Li, Suzanne J Baker*, Junmin Peng*. Deep multi-omics profiling of brain tumors identifies signaling networks downstream of cancer driver genes. Nature Communications. 2019.10(1):3718. (IF: 12.121)

9. Elizabeth Stewart#, Justina McEvoy#, Hong Wang#, Xiang Chen#, Victoria Honnell, Monica Ocarz, Brittney Gordon, Jason Dapper, Kaley Blankenship, Yanling Yang, Yuxin Li, Timothy I Shaw, Ji-Hoon Cho, Xusheng Wang, Beisi Xu, Pankaj Gupta, Yiping Fan, Yu Liu, Michael Rusch, Lyra Griffiths, Jongrye Jeon, Burgess B Freeman III, Michael R Clay, Alberto Pappo, John Easton, Sheila Shurtleff, Anang Shelat, Xin Zhou, Kristy Boggs, Heather Mulder, Donald Yergeau, Armita Bahrami, Elaine R Mardis, Richard K Wilson, Jinghui Zhang, Junmin Peng, James R Downing, Michael A Dyer*, St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. Identification of Therapeutic Targets in Rhabdomyosarcoma Through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018.34(3):411-426.e19. (IF:23.9)

10. Hong Wang#, Yanling Yang, Yuxin Li, Bing Bai, Xusheng Wang, Haiyan Tan, Tao Liu, Thomas G Beach, Junmin Peng?, Zhiping Wu?. Systematic optimization of long gradient chromatography mass spectrometry for deep analysis of brain proteome. Journal of Proteome Research. 2015 14(2):829-38. (IF: 4.173, C100)