解可波，研究員，博士研究生導(dǎo)師。本科、碩士畢業(yè)于山東大學(xué)，博士畢業(yè)于北京協(xié)和醫(yī)學(xué)院。國(guó)家優(yōu)秀青年科學(xué)基金獲得者。中華中醫(yī)藥學(xué)會(huì)青年委員。曾擔(dān)任Acta Pharmaceutica Sinica B與Chinese Chemical Letters等SCI期刊青年編委。

長(zhǎng)期從事藥用天然產(chǎn)物合成生物學(xué)研究，包括解析天然藥用分子生物合成機(jī)制，創(chuàng)建藥用分子生物合成細(xì)胞工廠；聯(lián)合酶-化學(xué)法的天然產(chǎn)物結(jié)構(gòu)優(yōu)化，用于新藥發(fā)現(xiàn)。先后解析了紫杉醇、巖白菜素等稀缺萜類及糖苷類藥用分子生源途徑，創(chuàng)建了細(xì)胞工廠。主持國(guó)自然優(yōu)秀青年科學(xué)基金、國(guó)自然原創(chuàng)探索及國(guó)自然面上等國(guó)家級(jí)項(xiàng)目；發(fā)表SCI論文20余篇，包括Angew Chem Int Ed、Nat Commun等國(guó)際權(quán)威期刊；申請(qǐng)專利20余項(xiàng)。

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1. Changkang Li#, Xinxin Yin#, Shuai Wang, Songyang Sui, Jimei Liu, Xincheng Sun, Jinming Di, Ridao Chen, Dawei Chen, Yaotian Han, Kebo Xie*, Jungui Dai*. A Cytochrome P450 Enzyme Catalyses Oxetane Ring Formation in Paclitaxel Biosynthesis. Angew. Chem. Int. Ed., 2024, e202407070. (IF 16.1)

2. Ruiqi Yan#, Binghan Xie#, Kebo Xie#*, Qi Liu#, Songyang Sui, Shuqi Wang, Dawei Chen, Jimei Liu, Ridao Chen, Jungui Dai* & Lin Yang*. Unravelling and reconstructing the biosynthetic pathway of bergenin. Nat. Commun., 2024, 15, 3539. (IF 14.7)

3. Kebo Xie#*, Qian Zhang#, Fei Ye, Jungui Dai*. A multi-enzymatic cascade reaction for the synthesis of bioactive C-oligosaccharides. Chin. Chem. Lett., 2024, 35, 109028. (IF 9.4).

4. Songyang Sui#, Kebo Xie#, Ruimingqian Guo, Jungui Dai*, and Lin Yang*. Molecular characterization of a stereoselective and promiscuous flavanone 3-hydroxylase from Carthamus tinctorius L. J. Agric. Food Chem., 2023, 71, 1679-1689. (IF 6.1)

5. Kebo Xie#*, Xiaolin Zhang#, Songyang Sui, Fei Ye* and Jungui Dai*. Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides. Nat. Commun., 2020, 11, 1-12 (IF 14.9).

6. Yujiao Zhang#, Kebo Xie#, Aijing Liu, Ridao Chen, Dawei Chen, Lin Yang, Jungui Dai* Enzymatic biosynthesis of benzylisoquinoline alkaloid glycosides via promiscuous glycosyltransferases from Carthamus tinctorius. Chin. Chem. Lett., 2019, 30, 443-446. (IF 4.63)

7. Tian Yue, Ridao Chen, Dawei Chen, Jimei Liu, Kebo Xie* and Jungui Dai*, Enzymatic Synthesis of Bioactive O-Glucuronides Using Plant Glucuronosyltransferases, J. Agric. Food Chem., 2019, 67, 6275-6284. (IF 4.2)

8. Kebo Xie, Ridao Chen, Dawei Chen, Jianhua Li, Ruishang Wang, Lin Yang and Jungui Dai*, Enzymatic N-Glycosylation of Diverse Arylamine Aglycones by a Promiscuous Glycosyltransferase from Carthamus tinctorius. Adv. Synth. Catal., 2017, 359, 603?608. (IF 5.1)

9. Kebo Xie#, Xiaoxiang Dou#, Ridao Chen, Dawei Chen, Cheng Fang, Zhiyan Xiao and Jungui Dai*, Molecular Characterization and Phylogenetic Analysis of Two Novel Fungal Phenolic UDP-Glycosyltransferases from Absidia coerulea and Rhizopus japonicus. Appl. Environ. Microbiol., 2017, AEM-03103. (IF 3.6)

10. Kebo Xie, Ridao Chen, Jianhua Li, Ruishan Wang, Dawei Chen, Xiaoxiang Dou, and Jungui Dai*, Exploring the catalytic promiscuity of a new glycosyltransferase from Carthamus tinctorius, Org. Lett., 2014, 16, 4874-4877. (IF 6.32, C100)