耿軼群,研究員,博士生導(dǎo)師。2001年考入北京大學(xué)藥學(xué)專業(yè),2005年獲得學(xué)士學(xué)位。2005-2007年在北京大學(xué)藥學(xué)院化學(xué)生物學(xué)專業(yè)攻讀碩士學(xué)位,從事糖化學(xué)研究。2007-2011年在北京大學(xué)藥學(xué)院化學(xué)生物學(xué)專業(yè)攻讀博士學(xué)位,從事糖化學(xué)生物學(xué)研究。曾作為第三完成人,獲國家自然科學(xué)二等獎(jiǎng)1項(xiàng)。獲得國家級(jí)優(yōu)秀青年人才項(xiàng)目、國家自然科學(xué)基金委面上項(xiàng)目、國家自然科學(xué)基金委青年科學(xué)基金等項(xiàng)目資助。
     院校引進(jìn)人才,2020年加入院校,曾在德國康斯坦茨大學(xué)化學(xué)系和英國牛津大學(xué)化學(xué)系進(jìn)行博士后研究工作,主要研究糖化學(xué)生物學(xué)和糖類藥物。
長期從事糖化學(xué)生物學(xué)和糖類藥物研究。運(yùn)用化學(xué)生物學(xué)研究范式,構(gòu)建前沿交叉技術(shù)體系,聚焦內(nèi)源性糖類活性物質(zhì)的高效獲取、功能解析和外源干預(yù),驅(qū)動(dòng)原創(chuàng)靶點(diǎn)發(fā)現(xiàn)和新藥創(chuàng)制。代表性成果以第一或通訊作者(含共同)在Nature,Nat. Commun., J. Am. Chem. Soc.等期刊發(fā)表論文20篇,入選海外青年人才項(xiàng)目,以第三完成人得國家自然科學(xué)二等獎(jiǎng),擔(dān)任中國化學(xué)會(huì)糖化學(xué)專委會(huì)等學(xué)會(huì)委員,近5年主持或參與國家和省部級(jí)課題7項(xiàng),發(fā)表論文8篇,申請(qǐng)專利8項(xiàng)。
1. Zhenghui Chen, Anhui Wang, Yiqun Geng*. Thermal proteome profiling of protein-centric interactions and modifications. Trends Biochem Sci. 2025, 50(6): 544-545. (IF=11.0)
2. Jie Li#, Wen Zhou#, Jianzhi Zhang#, Li Ma#, Zhuan Lv, Yiqun Geng*, Xing Chen*, Jing Li*. O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma. Fundam. Res. 2025, 5(5): 2388-2396. (IF=6.3)
3. Yanling Zhang*#, Yafei Cao#, Xia Wu, Zhenghui Chen, Bowen Chen, Anhui Wang, Yanshen Guo, Wei Chen, Ruolan Xue, Zihua Liu, Yuanpei Li, Tian Li, Ruiqin Cheng, Ning Zhou, Jing Li, Yuan Liu, Xiaohui Zhao, Huixin Luo, Ming Xu, Houhua Li*, Yiqun Geng*. Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase. Nat. Commun. 2024, 15, 8936. (IF=14.7)
4. Tian Li, Anhui Wang, Yanling Zhang, Wei Chen, Yanshen Guo, Xia Yuan, Yuan Liu, Yiqun Geng*. Chemoproteomic profiling of signaling metabolite fructose-1,6-bisphosphate interacting proteins in living cells. J. Am. Chem. Soc. 2024, 146(22): 15155-15166. (IF=14.4)
5. Tianlu Li*, Tong Li, Yue Yang, Haoru Zhuang, Jianwu Lv, Ning Zhou, Miaomiao Zhang, Fengshan Wang, Yiqun Geng*, Richard R. Schmidt*, Peng Peng*. Concise Synthesis of Lactococcus garvieae Lipoteichoic Acids Through an Additive-Modulated Preactivation Protocol and the Immunological Studies. CCS Chem. 2024, 6(2): 403-414. (IF=9.2)
6. Yingxin Shi#, Sheng Yan, Guang-Can Shao, Jinglong Wang, Yong-Ping Jian, Bo Liu, Yanqiu Yuan, Ke Qin, Shanshan Nai, Xiahe Huang, Yingchun Wang, Zhenghui Chen, Xing Chen, Meng-Qiu Dong, Yiqun Geng*, Zhi-Xiang Xu*, Jing Li*. O-GlcNAcylation stabilizes the autophagy-initiating kinase ULK1 by inhibiting chaperone-mediated autophagy upon HPV infection. J. Biol. Chem. 2022, 298(9): 102341.
7. Cara A. Griffiths#, Ram Sagar#, Yiqun Geng#, Lucia F. Primavesi, Mitul K. Patel, Melissa K. Passarelli, Ian S. Gilmore, Rory T. Steven, Josephine Bunch, Matthew J. Paul*, Benjamin G. Davis*. Chemical intervention in plant sugar-signalling increases yield and resilience. Nature 2016, 540 (7634): 574-578. (IF=40.1, C100, ESI,F1000)
8. Yiqun Geng#, Amit Kumar, Hassan M. Faidallah, Hassan A. Albar, Ibrahim, A. Mhkalid, Richard R. Schmidt*. Cooperative Catalysis in Glycosidation Reactions with O-Glycosyl Trichloroacetimidates as Glycsoyl Donors. Angew. Chem. Int. Ed. 2013, 52 (38): 10089-10092. (IF=11.3)