賈美榮,研究員,博士生導(dǎo)師。山東大學(xué)制藥工程專業(yè)學(xué)士,山東大學(xué)藥物化學(xué)專業(yè)碩士,美國Iowa State University生物化學(xué)專業(yè)博士,從事活性萜類生物合成研究。獲得北京市科技新星計(jì)劃等項(xiàng)目資助。
     院校引進(jìn)人才,2021年加入院校,曾在美國University of California, Davis進(jìn)行博士后研究工作,主要從事植物萜類合成生物學(xué)研究。
致力于藥用植物活性物質(zhì)的挖掘、生物合成和合成生物學(xué)研究。在國際上首次解析了中藥抗生素“穿心蓮內(nèi)酯”的完整生源途徑,結(jié)合人工智能,解析了多個(gè)萜類合酶的新催化機(jī)制,實(shí)現(xiàn)了眾多萜類產(chǎn)物的高效生物合成。迄今承擔(dān)10余項(xiàng)國家和省部級(jí)等科研課題,以第一或通訊作者在Angewandte Chemie International Edition、ACS Catalysis等國際期刊發(fā)表論文和論著30余篇。擔(dān)任植物代謝專業(yè)委員會(huì)委員以及《Chinese Journal of Natural Medicines》《Engineering Microbiology》《中國醫(yī)藥生物技術(shù)》等期刊(青年)編委。
1. Wang S#, Liang M#, Chen W#, Wan H, Meng X, Zhu X, Lu Y, Shen Q, Jiang C, Xie N, Chen S?, Jia M?, Sun W?, Completing the biosynthesis of the clinically important diterpenoid andrographolide in Andrographis paniculata. Angew Chem Int Ed. 2025: e202425303(IF = 16.1)
2. Li Y#, Mei Y, Schmidt-Dannert M, Lv Y, Peters R?, Jia M?, The pursuit of a hydroxylation switch uncovers a key residue for various product outcomes in the ent-kaurene synthase from Bradyrhizobium japonicum. Org Lett. 2025, 27, 3942?3946(IF = 4.9).
3. Sun X#, Zhang H, Jia Y, Li J?, Jia M?, CRISPR-Cas9-based genome-editing technologies in engineering bacteria for the production of plant-derived terpenoids. Eng Microbiol. 2024,100154.
4. Mei Y#, Liang M, Li J?, Jia M?. Transcriptome-based mining and functional characterization of class II diterpene synthases from Isodon eriocalyx. Chin Med Biotech. 2024, 19(3):206-213.
5. Muchlinski A#, Jia M#, Tiedge K#, Fell J, Pelot K, Chew L, Davisson D, Chen Y, Siegel J, Lovell J, and Zerbe P*. Cytochrome P450-catalyzed biosynthesis of furanoditerpenoids in the bioenergy crop switchgrass (Panicum virgatum L.). Plant J. 2021, 108: 1053–68 (IF = 6.417).
6. Jia M#, Zhang Y#, Siegel JB*, Tantillo DJ*, and Peters RJ*. Switching on a nontraditional enzymatic base–deprotonation by serine in the ent-kaurene synthase from Bradyrhizobium japonicum. ACS Catal. 2019, 9:8867-71 (IF = 11.406).
7. Jia M#, Mishra S, Tufts S, Jernigan R, and Peters RJ*. Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases. Metab Eng. 2019, 55:44-58 (IF = 7.875).
8. Jia M#, O’Brien TE, Zhang Y, Siegel JB, Tantillo DJ, and Peters RJ*. Changing face: A key residue for the addition of water by sclareol synthase. ACS Catal. 2018, 8:3133-7 (IF = 10.435).
9. Jia M#, Zhou K, Tufts S, Schulte S, and Peters RJ*. A pair of residues that interactively affect diterpene synthase product outcome. ACS Chem. Biol. 2017, 12(3):862-7 (IF = 5.139).
10. Jia M#, Potter KC, and Peters RJ*. Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis. Metab Eng. 2016, 37:24-34 (IF = 7.742).