范武發(fā)，研究員，博士生導(dǎo)師，課題組組長。復(fù)旦大學(xué)藥劑學(xué)博士，主要從事藥物遞送研究。擔任中國醫(yī)藥教育協(xié)會皮膚藥學(xué)專業(yè)委員會委員，Asian Journal of Pharmaceutical Sciences、Chinese Chemical Letters青年編委。獲得國家自然科學(xué)基金青年科學(xué)基金項目資助。
     院校引進人才，2022年加入院校，曾在北京大學(xué)化學(xué)與分子工程學(xué)院進行博士后研究工作，從事納米藥物遞送研究。

長期從事藥物遞送研究，通過合成高分子、脂質(zhì)材料，構(gòu)建智能納米藥物，實現(xiàn)腫瘤、中樞系統(tǒng)疾病的高效治療。具體包括納米藥物跨生物屏障遞送及機制；納米藥物腫瘤免疫治療；多肽、蛋白、核酸等大分子藥物遞送；納米藥物生物學(xué)效應(yīng)。目前發(fā)表10余篇SCI論文，其中以通訊作者/第一作者身份在Nature Biomedical Engineering、Advanced Materials、Advanced Drug Delivery Reviews、Nano Today等雜志發(fā)表9篇。

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1. Aocan Zhao#, Yisi Tang#, Xudong Shi*, Wufa Fan*. Interstitial drug delivery system: Physiological basis and (pre)clinical progress. J Control Release, 2025, 388, 114275. (IF: 11.5)

2. Yisi Tang#, Bao Liu#, Yuting Zhang#, Yuling Liu, Yongzhuo Huang*, Wufa Fan*. Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery. Adv Drug Deliv Rev, 2024, 209, 115304. (IF: 17.6)

3. Wufa Fan#, Jiajia Xiang#, Qiuyu Wei#, Yisi Tang#, Ying Piao, Shiqun Shao, Zhuxian Zhou*, Jianbin Tang, Zi-Chen Li*, Youqing Shen*. Role of micelle size in cell transcytosis-based tumor extravasation, infiltration, and treatment efficacy. Nano Lett, 2023, 23, 3904-3912. (IF: 9.6)

4. Wufa Fan#, Qiuyu Wei, Jiajia Xiang, Yisi Tang, Quan Zhou, Yu Geng, Yanpeng Liu, Rui Sun, Lei Xu, Guowei Wang, Ying Piao, Shiqun Shao*, Zhuxian Zhou, Jianbin Tang, Tao Xie, Zichen Li*, Youqing Shen*. Mucus penetrating and cell-binding polyzwitterionic micelles as potent oral nanomedicine for cancer drug delivery. Adv Mater 34(16):e2109189. (IF=32.086)

5. Wufa Fan#, Haixia Peng, Zhou Yu, Luting Wang, Haisheng He, Yuhua Ma, Jianping Qi, Yi Lu, Wei Wu*. The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers. Acta Pharm Sin B 12(5):2479-2493. (IF=14.903)

6. Siqin Chen#, Yin Zhong#, Wufa Fan#, Jiajia Xiang#, Guowei Wang, Quan Zhou, Jinqiang Wang, Yu Geng, Rui Sun, Zhen Zhang, Ying Piao, Jianguo Wang, Jianyong Zhuo, Hailin Cong, Haiping Jiang, Jun Ling, Zichen Li, Dingding Yang, Xin Yao, Xiao Xu, Zhuxian Zhou, Jianbin Tang, Youqing Shen*. Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion-drug conjugates with cell-membrane affinity. Nat Biomed Eng 5(9):1019-1037. (IF=29.234, ESI)

7. Yisi Tang#, Wufa Fan#, Guihua Chen, Meng Zhang, Xueping Tang, Hairui Wang, Pengfei Zhao, Qin Xu, Zhibing Wu*, Xiaoxi Lin, Yongzhuo Huang*. Recombinant cancer nanovaccine for targeting tumor-associated macrophage and remodeling tumor microenvironment. Nano Today 40:101244. (IF=18.962)

8. Wufa Fan#, Zhou Yu#, Haixia Peng, Haisheng He, Yi Lu, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu*. Effect of particle size on the pharmacokinetics and biodistribution of parenteral nanoemulsions. Int J Pharm 586:119551. (IF=5.875)

9. Zhou Yu#, Wufa Fan#, Luting Wang, Haisheng He, Yongjiu Lv, Jianping Qi, Yi Lu, Wei Wu*. Slowing down lipolysis significantly enhances the oral absorption of intact solid lipid nanoparticles. Biomater Sci 7(10):4273-4282. (IF=6.183)