龔佳男，研究員，博士研究生導(dǎo)師。曾獲教育部高等學(xué)校自然科學(xué)獎(jiǎng)二等獎(jiǎng)；獲得國(guó)家自然科學(xué)基金面上項(xiàng)目（2025）、國(guó)家自然科學(xué)基金青年項(xiàng)目（2023）、北京市科技新星（2021）等項(xiàng)目資助。 院校引進(jìn)人才，2020年加入院校。2013年11月-2020年9月在墨爾本大學(xué)生物醫(yī)學(xué)系/The Walter and Eliza Hall Institute of Medical Research 醫(yī)學(xué)研究所開展博士后訓(xùn)練。

長(zhǎng)期從事腫瘤模型研制、癌變機(jī)理及轉(zhuǎn)化應(yīng)用研究。以第一或通訊作者（含共同）在Cancer Discovery、Blood (x2)、Cell Death and Differentiation（x2）等雜志發(fā)表研究型論文10余篇，授權(quán)發(fā)明專利1項(xiàng)。與上海華博、北京百濟(jì)神州、中國(guó)醫(yī)學(xué)科學(xué)院藥物研究所等機(jī)構(gòu)合作，利用疾病模型完成多個(gè)抗腫瘤新藥和幽門螺桿菌mRNA疫苗的藥效學(xué)評(píng)價(jià)。

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1. Jia-Nan Gong^#*, Tirta M Djajawi, Donia M Moujalled, Giovanna Pomilio, Tiffany Khong, Li-Ping Zhang, Pasquale L Fedele, Michael S Low, Mary Ann Anderson, Christopher D Riffkin, Christine A White, Ping Lan, Guillaume Lessene, Marco J Herold, Andreas Strasser, Andrew Spencer, George Grigoriadis, Andrew H Wei, Mark F van Delft, Andrew W Roberts^* and David C Huang^*. Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro?survival BCL2 proteins. Cell Death & Differentiation. 2025; 32, 1382–1396.（IF:15.4）

2. Zhang LP, Wei YM, Luo MJ, Ren SY, Zhan XW, Wang C, Li ZF, Zhu RM, Yan S, Cheng Y, Xu JL, Yang XJ, Du KL, Wang JQ, Zhang GN, Du DX, Gao R, Zhao DB, Gong JN^*. Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer. Cell Death & Disease. 2025;16(1):170. (IF:9.6）

3. Chao Wang, Guo-Min Xie, Li-Ping Zhang, Shuo Yan, Jia-Li Xu, Yun-Lin Han, Ming-Jie Luo, Jia-Nan Gong^*. High Engraftment and Metastatic Rates in Orthotopic Xenograft Models of Gastric Cancer via Direct Implantation of Tumor Cell Suspensions. Cancers (Basel). 2024;16(4):759. (IF:4.5)

4. Yumin Wei, Liping Zhang, Chao Wang, Zefeng Li, Mingjie Luo, Guomin Xie, Xingjiu Yang, Mengyuan Li, Shuyue Ren, Dongbing Zhao^*, Ran Gao^*, Jia-Nan Gong* Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer. Animal Model Exp Med. 2023;6(3):245-254.

5. Ming?Jie Luo, Michelle Palmieri, Chris D Riffkin, Anuratha Sakthianandeswaren, Tirta Mario Djajawi, Yumiko Hirokawa, Victoria Shuttleworth, David H Segal, Christine A White, Duong Nhu, Guillaume Lessene, Margaret Lee, Peter Gibbs, David CS Huang^*, Oliver M Sieber^* and Jia-Nan Gong^*. Define the susceptibility of colorectal cancers to BH3 mimetic compounds. Cell Death & Disease. 2020;11(9):735. (IF:8.469)

6. Piers Blombery^#, Mary Ann Anderson^#, Jia-nan Gong^#, Rachel Thijssen^#, Richard W.Birkinshaw^#, Ella Thompson, Charis E. Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E. Lew, Ian J. Majewski, Daniel H.D. Gray, David A. Westerman, Constantine S. Tam, John F. Seymour, Peter E. Czabotar, David C.S. Huang, Andrew W. Roberts. Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia. Cancer Discovery. 2019;9(3):342-353. (C100; IF:26.37）)

7. Jia-nan Gong^#, Tiffany Khong, David Segal, Yuan Yao, Chris D. Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J. Herold, Andrew W. Roberts, David C. S. Huang. Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1. Blood. 2016;128(14):1834-1844. (Cover story; C100; IF：13.164)

8. Gong JN^#, Yu J^#, Lin HS^#, Zhang XH, Yin XL, Xiao Z, Wang F, Wang XS, Su R, Shen C, Zhao HL, Ma YN, Zhang JW. The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia. Cell Death Differ. 2014;21(1):100-12. (C100; IF:8.184)

9. Jia-nan Gong^#, Jianxiong Li^#, Yi Wang^#, Changzheng Liu^#, Hongyan Jia, Chongliang Jiang, Yuxuan Wang, Min Luo, Hongmei Zhao, Lei Dong, Fang Wang, Junwu Zhang, Jia Yu. Characterization of microRNA-29 family expression and investigation of their mechanistic and therapeutic roles in gastric cancer. Carcinogenesis. 2014; 35(2):497-506. (C100; IF:4.004)

10. Xiao-Shuang Wang^#, Jia-Nan Gong^#, Jia Yu, Fang Wang, Xin-Hua Zhang, Xiao-Lin Yin, Zhen-Qing Tan, Zi-Mian Luo, Gui-Hua Yang, Chao Shen, Jun-Wu Zhang. MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood. 2012; 119:4992 -5004. (C100; ESI; IF:9.06）