賀海燕，研究員，博士生導師，副所長。2007年本科畢業(yè)于天津大學。2012年于中國科學院上海有機化學研究所獲生命有機化學博士學位。獲國家海外引進高層次人才青年項目、國家自然科學基金-面上等項目資助。 院校引進人才，2021年加入院校，曾在加拿大英屬哥倫比亞大學任職博士后/助理研究員。

長期從事降糖降脂及抗腫瘤藥物的發(fā)現(xiàn)及結(jié)構(gòu)優(yōu)化，綠色生物合成等領域的研究。發(fā)現(xiàn)并揭示了多個藥用活性天然產(chǎn)物的生物合成途徑，闡明了十余個具有新穎功能酶的催化機制，可應用于天然產(chǎn)物和臨床藥物的結(jié)構(gòu)修飾及改造。主持或參于國家和省部級科研課題6項，在Chem Soc Rev, Nat Chem, JACS，Angew Chem等領域內(nèi)著名學術(shù)期刊發(fā)表論文十余篇，他因700余次。

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1. Yun Wang#, Jiangtao Zhang, Ran Shi, Siyuan Zhou, Shigui Chen, Ruofei Li*, Wei Huang*, Hai-Yan He*, Nitramine Formation via a Cryptic Non-Ribosomal Peptide Synthetase-Dependent Strategy in N-Nitroglycine Biosynthesis. Angew. Chem. Int. Ed. 2025, e202507866. (IF=16.1)

2. Songya Zhang#, Shuai Fan#, Haocheng He#, Jing Zhu, Lauren Murray, Gong Liang, Shi Ran, Yi Zhun Zhu, Max J Cryle*, Hai-Yan He*, Youming Zhang*. Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles. Chem. Soc. Rev. 2025, 54, 396-464. (IF=40.4)

3. Hai-Yan He*, Haruka Niikura, Yi-Ling Du, Katherine S. Ryan*. Synthetic and biosynthetic routes to nitrogen-nitrogen bonds. Chem. Soc. Rev. 2022, 51, 2991-3046. (IF=60.6)

4. Hai-Yan He#, and Katherine S. Ryan*. Glycine-derived Nitronates Bifurcate Between O-Methylation and Denitrification in Bacteria. Nat. Chem. 2021, 13, 599-606. (IF=19.2)

5. Hai-Yan He#, Alyssa C. Henderson, Yi-Ling Du, and Katherine S. Ryan*. Two-Enzyme Pathway Links L-Arginine to Nitric Oxide in N-Nitroso Biosynthesis. J. Am. Chem. Soc. 2019, 141, 4026–4033. (IF=14.6)

6. Hai-Yan He#, Man-Cheng Tang, Feng Zhang, and Gong-Li Tang*. Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis. J. Am. Chem. Soc. 2014, 136, 4488–4491. (IF=12.1)

7. Hai-Yan He#, Hua Yuan, Man-Cheng Tang, and Gong-Li Tang*. An Unusual Dehydratase Acting on Glycerate and a Ketoreductase Stereoselectively Reducing a-Ketone in Polyketide Starter Unit Biosynthesis. Angew. Chem. Int. Ed. 2014, 53, 11315 –11319. (IF=13.7)