王真，中國醫(yī)學(xué)科學(xué)院醫(yī)藥生物技術(shù)所研究員、博士生導(dǎo)師，生化室主任。1997年畢業(yè)于山東醫(yī)科大學(xué)臨床醫(yī)學(xué)專業(yè)，獲學(xué)士學(xué)位；2002畢業(yè)于中國協(xié)和醫(yī)科大學(xué)微生物與生化藥學(xué)，獲博士學(xué)位。2002年至今在中國醫(yī)學(xué)科學(xué)院醫(yī)藥生物技術(shù)研究所工作至今，2002-2004和2004-2006分別在新加坡基因組研究院和美國密西根大學(xué)做博士后研究。2011年9月起陸續(xù)任醫(yī)藥生物技術(shù)研究所研究員、博士生導(dǎo)師、生化室主任。2024年1月入選北京協(xié)和醫(yī)學(xué)院準(zhǔn)聘長聘系列助理教授。主持完成七項(xiàng)國家自然科學(xué)基金項(xiàng)目。作為主要貢獻(xiàn)者曾獲北京科技三等獎。

長期從事腫瘤和炎癥代謝病的病理機(jī)制和相關(guān)藥物藥理研究，闡述了多個調(diào)控腫瘤轉(zhuǎn)移、凋亡抵抗和周期進(jìn)展的蛋白穩(wěn)態(tài)新機(jī)制以及調(diào)節(jié)骨代謝穩(wěn)態(tài)的新表觀遺傳機(jī)制；發(fā)現(xiàn)了多種抗腫瘤或抗骨質(zhì)疏松藥物的新作用機(jī)制。作為通訊或第一作者在Cell Death Differ, Cancer Lett, Cancer Res, Kidney Int, Oncogene, J Bone Miner Res, Faseb J等國際知名期刊發(fā)表SCI文章30余篇，其中多篇通訊作者文章超過100次引用。累計獲引用2230余次，H指數(shù)27。以主要發(fā)明人獲授權(quán)中國專利七項(xiàng)。

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1. Zheng L#, Shen J#, Chen Y, Lin J, Li P, Zhao X, Ren H, Sun Y*, Wang Z*. FBXO43 promotes cell cycle progression in cancer cells through stabilizing SKP2. Cancer Letters. 2024:591:216848. (IF=10.1)

2. Zhao X#, Lin S#, Ren H#, Sun S, Zheng L, Chen LF, Wang Z*. The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis. Cell Death and Differentiation 2024, 31(5):605-617. (IF=15.4)

3. Shen J#, Yang H#, Qiao X, Chen Y, Zheng L, Lin J, Lang J, Yu Q, Wang Z*. The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis. Cell Death and Differentiation 2023, 30(10): 2322-2335. (IF=13.7)

4. Qiao X#, Lin J#, Shen J, Chen Y, Zheng L, Ren H, Zhao X, Yang H, Li P, Wang Z*. FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation. Oncogene 2023, 42(39):2878-2891. (IF=8)

5. Li H#, Zhao X#, Zheng L, Wang X, Lin S, Shen J, Ren H, Li Y, Qiu Q, Wang Z*. Bruceine A protects against diabetic kidney disease via inhibiting galectin-1. Kidney International 2022, 102(3): 521-535. (IF=19.6)

6. Zhao X, Lin S, Li H, Si S*, Wang Z*. Myeloperoxidase controls bone turnover by suppressing osteoclast differentiation through modulating reactive oxygen species level. Journal of Bone and Mineral Research. 2021, 36(3):591-603.

7. Shen J, Zhan Y, Li H and Wang Z*, Ouabain impairs cancer metabolism and activates AMPK-Src signaling pathway in human cancer cell lines. Acta Pharmacologica Sinica, 2020 Jan;41(1):110-118.

8. Shen J, Li P, Shao X, Yang Y, Liu XJ, Feng M, Yu Q, Hu R*, Wang Z*. The E3 ligase RING1 targets p53 for degradation and promotes cancer cell proliferation and survival. Cancer Research 2018, 78(2):359-371. (IF=8.38)

9. Wang Y, Qiu Q, Shen J, Li D, Jiang X, Si S, Shao R*, Wang Z*. Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways. International Journal of Biochemistry & Cell Biology 2012, 44(11):1813-1824. (IF=4.15, C100)

10. Wang Z#, Zheng M#, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y*. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research 2009, 69(16): 6556-6564. (IF=7.53)