付海根，研究員，博士研究生導(dǎo)師。2019年于荷蘭格羅寧根大學(xué)獲得制藥生物學(xué)博士學(xué)位，主要從事酶催化藥物合成研究。獲得國(guó)家海外引進(jìn)高層次人才青年項(xiàng)目資助。 院校引進(jìn)人才，2023年加入院校。2020年至2022年先后在美國(guó)普林斯頓和康奈爾大學(xué)從事博士后研究，方向?yàn)榉翘烊还饷复呋?

長(zhǎng)期從事發(fā)展新的生物催化方法學(xué)用于藥物的研發(fā)和制備。發(fā)展了多種從基態(tài)到激發(fā)態(tài)活化模式的酶催化非天然自由基反應(yīng)，實(shí)現(xiàn)了首例光酶催化不對(duì)稱親電偶聯(lián)反應(yīng)以及多種挑戰(zhàn)性的自由基型不對(duì)稱轉(zhuǎn)化；實(shí)現(xiàn)了生物催化軸手性胺骨架的不對(duì)稱合成；首次完成金屬-β-內(nèi)酰胺酶抑制劑AMA的化學(xué)-酶法全合成。承擔(dān)3項(xiàng)國(guó)家級(jí)科研課題，在Nature、Nature Catalysis、JACS、Angew等雜志發(fā)表論文20余篇，H指數(shù)21。培養(yǎng)在讀博士、碩士研究生9名。

午夜92福利1000,午夜92福利1000,久久国产亚洲高清观看5388,美女不拍网站免费观看,欧美***天天久久综合精品,中文字幕日韩系列中文字幕,综合久久国产九一剧情麻豆,丰满人妻在线免费视频,奶子大逼又嫩操起来真爽

1. K. Li^#, Z. Liu^#, B. Wang, L. Huang, L. Yu, Z. Zhou, L. Lin*, P. Fang*, and H. Fu*. Imine reductase–catalyzed remote stereocontrol for enantiodivergent synthesis of cyclohexylidene-based axially chiral amines. Angew. Chem. Int. Ed. 2025, 64 (30), e202500572. (IF = 16.9)

2. X. Hao^#, Z. Tian^#, Z. Yao^#, T. Zang, S. Song, L. Lin, T. Qiao, L. Huang*, H. Fu*. Atroposelective synthesis of axial biaryls by dynamic kinetic resolution using engineered imine reductases. Angew Chem. Int. Ed. 2024, 63 (41), e202410112. (IF = 16.1)

3. H. Fu^#, T. Qiao^#, J.M. Carceller, S.N. MacMillan, T.K. Hyster*. Asymmetric C-alkylation of nitroalkanes via enzymatic photoredox catalysis. J. Am. Chem. Soc. 2023, 145 (2), 787–793. (IF = 14.1)

4. H. Fu^#, J. Cao, T. Qiao, Y. Qi, S.J. Charnock, S. Garfinkle, T.K. Hyster*. An asymmetric sp³–sp³ cross-electrophile coupling using ‘ene’-reductases. Nature 2022, 610 (7931), 302–307. (IF = 69.5)

5. H. Fu^#, H. Lam, M. Emmanuel, J.H. Kim, B.A. Sandoval, T.K. Hyster*. Ground state electron transfer as an initiation mechanism for biocatalytic C–C bond forming reactions. J. Am. Chem. Soc. 2021, 143 (25), 9622–9629. (IF = 16.4)

6. H. Fu^#, J. Zhang^#, M. Saifuddin^#, G. Cruiming, P.G. Tepper, G.J. Poelarends*. Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor Aspergillomarasmine A and related aminocarboxylic acids. Nat. Catal., 2018, 1 (3), 186–189. (IF = 30.5)