郭正彥，研究員，博士生導(dǎo)師。曾入選中國科學(xué)院青年創(chuàng)新促進會第七批會員。 院校引進人才，2021年加入院校。曾在中國科學(xué)院微生物研究所任副研究員，研究方向微生物與生物藥學(xué)。

長期從事微生物藥源分子的高效發(fā)現(xiàn)、生物合成及合成生物學(xué)研究。目前已經(jīng)完成了鏈絲菌素、春雷霉素、庚糖殺菌素、白黃菌素、喹噠霉素等多種微生物天然產(chǎn)物（藥物）的生物合成研究，拓展藥物分子的來源，為新藥物的可持續(xù)創(chuàng)制的提供保障。主持和承擔10余項國家和省部級科研課題，在Nat. Biotech.，J. Am. Chem. Soc.，Angew.Chem.Int.Ed.，Proc. Natl. Acad. Sci. USA，Acta Pharm. Sin B.等學(xué)術(shù)期刊發(fā)表論文40多篇，申請專利12項。現(xiàn)為中國醫(yī)藥生物技術(shù)協(xié)會酶工程與發(fā)酵工程專委會委員, 中國微生物學(xué)會微生物藥物與天然產(chǎn)物專委員委員。

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1. Yang, X. #,  Li, S. #, Feng, Y., Guo, Y., Guo, Z. *, and Hu, Y*. A novel extracellular mannan from Bacillus velezensis ameliorates metabolic-associated fatty liver disease by modulating gut microbiota in mice model. Carbohydrate Polymer 2025, 368(15): 124150-124170 (IF=12.5)

2. Li, C. #, Ma, J. #, Guo, L., Xu, C., Zhong, Z., Li, P., Tang, Y., Wang, W., Li, D., Ye, T., Guo, Z.*, and Chen, Y.* Selective synthesis of cyclopeptides with a 2-oxindole or 3a-Hydroxy-hexahydropyrrolo-[2,3-b]indole structure by cytochrome P450 Enzymes. Journal of the American Chemical Society 2025, 147(4): 3304-3314. (IF=14.5)

3. Li, K.; Guo, Z.*; Bai, L.* Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products. Synthetic Systems Biotechnology 2024, 9 (4), 701-712. (IF=4.40)

4. Chen, M., # Guo, Z. #, Sun, J., # Tang, W., Wang, M., Tang, Y., Li, P., Wu, B.*, and Chen, Y.* Insights into the biosynthesis of septacidin L-heptosamine moiety unveils a VOC family sugar epimerase. Acta Pharmaceutica Sinica B 2023, 13 (2): 765-774. (IF=14.8)

5. Ma, Y. #, Guo, Z. #, Xia, B. #, Zhang, Y. #, Liu, X., Yu, Y., Tang, N., Tong, X., Wang, M., Ye, X., Feng, J., Chen, Y. *, and Wang, J.* Identification of antimicrobial peptides from the human gut microbiome using deep learning. Nature Biotechnology 2022, 40: 921-931. (C100, IF=68.2)

6. Guo, Z.; Tang, Y.; Tang, W.; Chen, Y.* Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses. Natural Products Reports 2021, 38(10):1887-1909. (IF=13.42)

7. Tang, W., Chen, M., Li, P., Tang, Y., Wang, M., Guo, Z.*, and Chen, Y.* Biosynthesis of the N⁶-glycosylated L-heptosamine-adenine core in septacidin. Organic Letters 2020, 22 (13), 5251-5254. (IF=6.09)

8. Guo, Z.#, Li, P. #, Chen, G. #, Li, C., Cao, Z., Zhang, Y., Ren, J., Xiang, H., Lin, S., Ju, J., and Chen, Y.* Design and biosynthesis of dimeric alboflavusins with biaryl linkages via regiospecific C-C bond coupling. Journal of American Chemistry Society 2018, 140: 18009-18015. (IF=14.5)

9. Tang, W.#, Guo, Z.#, Cao, Z., Wang, M., Li, P., Meng, X., Zhao, X., Xie, Z., Wang, W., Zhou, A., Lou, C., and Chen, Y.* d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B. P Natl Acad Sci USA 2018, 115: 2818-2823. (IF=9.4)

10. Guo, Z.#, Li, J.#, Qin, H. #, Wang, M., Lv, X., Li, X., Chen, Y.* Biosynthesis of the carbamoylated D-gulosamine moiety of streptothricins: involvement of a guanidino-N-glycosyltransferase and an N-acetyl-D-gulosamine deacetylase. Angewandte Chemie-International Edition 2015, 54 (17): 5175-5178. (IF=11.7)