張轉(zhuǎn)，中國醫(yī)學(xué)科學(xué)院醫(yī)藥生物技術(shù)所研究員，博士生導(dǎo)師， 2008年本科畢業(yè)于陜西師范大學(xué)化學(xué)系，2014年博士畢業(yè)于中國科學(xué)院上海有機(jī)化學(xué)研究所。獲得國家海外引進(jìn)高層次人才青年基金、面上基金等項(xiàng)目資助。 院校引進(jìn)人才，2022年加入院校，曾在中國科學(xué)院上海有機(jī)化學(xué)研究所擔(dān)任研究助理（2014-2017），和美國加州大學(xué)洛杉磯分校（2017-2020）以及美國德克薩斯大學(xué)休斯頓健康科學(xué)中心(2020-2022)從事博士后研究。

研究聚焦于活性先導(dǎo)分子的發(fā)現(xiàn)，特別是抗真菌和免疫抑制劑，并解析其生物合成機(jī)制。通過合成生物學(xué)策略，挖掘與設(shè)計高效的酶催化元件，以實(shí)現(xiàn)藥物綠色智造。同時，課題組還開展抗真菌藥物耐藥性機(jī)制研究，為應(yīng)對藥物耐藥挑戰(zhàn)提供新思路。目前，團(tuán)隊(duì)已在Nat Chem Biol、J Am Chem Soc、Angew Chem Int Ed、PNAS 等國際頂尖學(xué)術(shù)期刊上以第一或通訊作者發(fā)表研究論文9篇，具備扎實(shí)的研究基礎(chǔ)與持續(xù)的創(chuàng)新能力。

午夜92福利1000,午夜92福利1000,久久国产亚洲高清观看5388,美女不拍网站免费观看,欧美***天天久久综合精品,中文字幕日韩系列中文字幕,综合久久国产九一剧情麻豆,丰满人妻在线免费视频,奶子大逼又嫩操起来真爽

(1) Qiang Dong#, Niandi Zhang#, Xiaorong Chen#, Jiayi Xuan, Tai Huang, Bo Niu, Zhefei Xu, Qingsong Chen, Jiayi Hu, Zhuan Zhang*, Song Meng*. Concise side-chain macrocyclization in Ahp-bicyclodepsipeptides biosynthesis involves cytochrome P450-catalyzed sequential aromatic hydroxylation and C─N coupling, Angewandte Chemie International Edition, 2025, doi.org/10.1002/anie.202513520. (IF= 16.5)

(2) Chao Yu, Niandi Zhang, Jinmei Li, Mingxin Zheng, Meihui Zhao, Ling-yan Wang, Zhiqiang An*, Gerald F Bills* and Zhuan Zhang*. Concise biosynthesis of antifungal papulacandins, 2025, 147(11): 9037-9042. (IF= 15.6)

(3) Lee Joon Kim#, Masao Ohashi#, Zhuan Zhang#, Dan Tan, Matthew Asay, Duilio Cascio, José A. Rodriguez, Yi Tang* and Hosea M. Nelson*. Prospecting for natural products by genome mining and microcrystal electron diffraction, Nature Chemical Biology, 2021, 17(8): 872-877. (IF= 16.3)

(4) Zhuan Zhang, Yui Tamura, Mancheng Tang, Tianzhang Qiao, Michio Sato, Yoshihiro Otsu, Satoshi Sasamura, Masatoshi Taniguchi, Kenji Watanabe* and Yi Tang*. Biosynthesis of the Immunosuppressant (?)-FR901483, Journal of the American Chemical Society, 2020, 143(1): 132-136. (IF= 15.4)

(5) Zhuan Zhang, Tianzhang Qiao, Kenji Watanabe* and Yi Tang*. Concise Biosynthesis of Phenylfuropyridones in Fungi, Angewandte Chemie International Edition, 2020, 59(45): 19889-19893. (IF= 13.5)

(6) Zhuan Zhang, Cooper S. Jamieson, Yi-Lei Zhao, Dehai Li, Masao Ohashi*, K. N. Houk* and Yi Tang*. Enzyme-Catalyzed Inverse-Electron Demand Diels?Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H, Journal of the American Chemical Society, 2019, 141(14): 5659-5663. (IF= 14.7, C100)

(7) Yu Hu#, Zhuan Zhang#, Yue Yin, Gong-Li Tang*. Directed Biosynthesis of Iso-aclacinomycins with Improved Anticancer Activity, Organic Letters, 2019, 22(1): 150-154. (IF= 6.1)

(8) Zhuan Zhang#; Yu-Kang Gong#; Qiang Zhou; Yu Hu; Hong-Min Ma; Yong-Sheng Chen; Yasuhiro Igarashi; Lifeng Pan*; Gong-Li Tang*. Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade, Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(7): 1554-1559. (IF= 9.5)