孫海濤,研究員,博士生導(dǎo)師。2009年獲得北京聯(lián)合大學(xué)生物技術(shù)專業(yè)學(xué)士學(xué)位。2012年獲得首都師范大學(xué)生物化學(xué)與分子生物學(xué)專業(yè)碩士學(xué)位。2019年獲得中國農(nóng)業(yè)大學(xué)生物學(xué)院微生物學(xué)專業(yè)博士學(xué)位。2023年獲得國家海外高層次青年人才項(xiàng)目資助。
     院校引進(jìn)人才,2023年加入藥用植物研究所。曾于2019年至2023年在美國City of Hope National Medical Center進(jìn)行博士后研究工作,主要研究DNA復(fù)制和腫瘤耐藥性機(jī)制。
長期從事基因組穩(wěn)定性維持機(jī)制和抗腫瘤新藥的研究,包括:DNA復(fù)制和損傷修復(fù)機(jī)制及腫瘤細(xì)胞基因組不穩(wěn)定性;抗腫瘤的新藥靶點(diǎn)發(fā)現(xiàn)和創(chuàng)新藥物研發(fā);腫瘤細(xì)胞對(duì)DNA復(fù)制的依賴性。發(fā)表科研論文13篇,其中以第一/通訊(共同)作者發(fā)表論文8篇,代表性成果發(fā)表于《Science》等高水平期刊,授權(quán)中國專利2項(xiàng)和美國專利1項(xiàng)。
1.Bin Li#, Qi Xiao#, Hongmei Zhao#, Jianuo Zhang, Chunyan Yang, Yucen Zou, Bengang Zhang, Jiushi Liu, Haitao Sun*, Haitao Liu*. Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism. Acta. Pharm. Sin. B., 2024, 14(9): 3949-3963. (IF=14.7)
2.Haitao Sun#*, Megan Luo#, Mian Zhou, Li Zheng, Hongzhi Li, R Steven Esworthy, Binghui Shen*. Structure-specific nucleases in genome dynamics and strategies for targeting cancers. J. Mol. Cell Biol., 2024, 16(5): mjae019. (IF=5.3)
3.Haitao Sun#, Lingzi Ma, Ya-fang Tsai, Tharindu Abeywardana, Binghui Shen*, Li Zheng*. Okazaki fragment maturation: DNA flap dynamics for cell proliferation and survival. Trends Cell Biol., 2023, 33(3): 221-234. (IF=21.1)
4.Lingzi Ma#, Haitao Sun#, Tharindumala Abeywardana, Li Zheng*, Binghui Shen*. Structure-specific nucleases: role in Okazaki fragment maturation. Trends Genet., 2022, 38(8):793-796. (IF=11.8)
5.Haitao Sun#, Zhaoning Lu, Amanpreet Singh, Yajing Zhou, Eric Zheng, Mian Zhou, Jinhui Wang, Xiwei Wu, Zunsong Hu, Zhaohui Gu, Judith L Campbell, Li Zheng* and Binghui Shen*. Error-prone, stress-induced 3' flap-based Okazaki fragment maturation supports cell survival. Science, 2021, 374(6572): 1252-1258. (IF=63.8)
6.Haitao Sun#, Jiaxin Zhang, Siyu Xin, Meiqian Jiang, Jingjing Zhang, Zhen Li, Qinhong Cao* and Huiqiang Lou*. Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2. PLoS Genet., 2019,15(2): e1007685. (IF=5.2)