劉明洋，中國(guó)醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院分子腫瘤學(xué)全國(guó)重點(diǎn)實(shí)驗(yàn)室研究員，課題組長(zhǎng)，醫(yī)科院準(zhǔn)聘助理教授，博士生導(dǎo)師，國(guó)家海外高層次青年人才，北京市杰青。以第一或通訊作者先后在Cancer Cell, Gastroenterology (五篇) , Journal of Clinical Investigation, Clinical Cancer Research, Cancer Research等雜志發(fā)表30余篇SCI論文。主持國(guó)自然基金面上項(xiàng)目等?，F(xiàn)為Pancreas和Pancreatology雜志副主編，Cancer Letters雜志編委?，F(xiàn)為中國(guó)抗癌協(xié)會(huì)青年理事會(huì)理事，中國(guó)醫(yī)療保健促進(jìn)會(huì)胰腺病學(xué)分會(huì)常委，國(guó)際肝膽胰協(xié)會(huì)中國(guó)分會(huì)胰腺腫瘤專業(yè)常委。院校引進(jìn)人才。
長(zhǎng)期從事胰腺癌惡病質(zhì)發(fā)生機(jī)制，化療免疫耐藥機(jī)制研究。發(fā)現(xiàn)巨噬細(xì)胞通過(guò)與腫瘤細(xì)胞互作促進(jìn)胰腺癌細(xì)胞分泌惡病質(zhì)因子，誘導(dǎo)肌肉萎縮和惡病質(zhì)（Cancer Cell, 2024）; 發(fā)現(xiàn)胰腺癌細(xì)胞分泌miR-203a通過(guò)激活肌肉細(xì)胞內(nèi)ZEB1-SLC11A2通路誘導(dǎo)肌肉鐵死亡，促進(jìn)肌肉萎縮（Cancer Letters, 2025）。在胰腺癌耐藥方面，發(fā)現(xiàn)對(duì)化療耐藥的腫瘤細(xì)胞高表達(dá)ZEB1，通過(guò)去乙?；疌XCL16，抑制GZMA+CD8+T細(xì)胞的浸潤(rùn)，招募免疫抑制性中性粒細(xì)胞招募，降低腫瘤細(xì)胞對(duì)化療藥及anti-PD1的響應(yīng)（Journal of Clinical Investigation, 2025）。
1. Zhang S#, Hu Y#, Zhou Z#, Lv G, Zhang C, Guo Y, Wang F, Ye Y, Qi H, Zhang H, Wu W, Li M*, Liu M*. ZEB1 promotes chemo-immune resistance in pancreatic cancer models by downregulating chromatin acetylation of CXCL16. J Clin Invest. 2025 Sep 9:e195970. (IF=13.6)
2. Hu Y#, Hu Y#, Zhang S#, Guo Y, Wang F, Du Y, Wang L, Li P, Xu Y, Zhang H, Yang Z, Liu Z, Xu J*, Liu M*. Tumor-derived miR-203a-3p potentiates muscle wasting by inducing muscle ferroptosis in pancreatic cancer. Cancer Lett. 2025 Apr 1;614:217523. (IF=9.1)
3. Liu M#, Ren Y#, Zhou Z#, Yang J#, Shi X#, Cai Y#, Arreola AX, Luo W, Fung KM, Xu C, Nipp RD, Bronze MS, Zheng L, Li YP, Houchen CW, Zhang Y*, Li M*. The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia.Cancer Cell. 2024 May 13;42(5):885-903.(IF=50.3)
4. Wu J #, Zhou J#, Li J#, Liu H#, Zhang H, Zhang J, Huang W, He Y, Zhu S, Huo M*, Liu M*, Zhang C*. CHD4 Promotes Acquired Chemoresistance and Tumor Progression by Activating MVP/ERK Axis. Drug Resist Updat. 2023 Jan;66:100913. (IF=24.3)
5. Liu M#, Zhang Y#, Yang J#, Zhan H#, Zhou Z, Jiang Y, Shi X, Luo W, Fung K, Xu C, Bronze M, Houchen CW, Li M*. Zinc Dependent Regulation of ZEB1 and YAP1 Co-activation Promotes EMT Plasticity and Metastasis in Pancreatic Cancer. Gastroenterology. 2021 Apr;160(5):1771-1783.(IF=22.682, C100)
