高亦博，1984年生，籍貫遼寧海城，國家自然科學基金委優(yōu)青，國家重點研發(fā)計劃首席科學家?，F(xiàn)為國家癌癥中心/國家惡性腫瘤臨床醫(yī)學研究中心/中國醫(yī)學科學院腫瘤醫(yī)院轉(zhuǎn)化醫(yī)學實驗室主任，博士生導師；胸外科主治醫(yī)師、副研究員、實驗室主管。清華大學、北京協(xié)和醫(yī)學院臨床醫(yī)學、腫瘤學博士，美國杜克大學醫(yī)學中心訪問學者。

主要開展食管癌、肺癌等胸部腫瘤的基因組測序、表觀遺傳、多組學分子分型和精準醫(yī)學研究，探究表觀遺傳和代謝重編程調(diào)控癌癥發(fā)生發(fā)展和療效預后的分子機制，篩選和驗證腫瘤精準診療生物標志物。

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1. Zhou X#, Yao Z#, Bai H, Duan J, Wang Z, Wang X, Zhang X, Xu J, Fei K, Zhang Z, Tan F, Xue Q, Gao S, Gao Y*, Wang J*, He J*. Treatment-related adverse events of PD-1 and PD-L1 inhibitor-based combination therapies in clinical trials: a systematic review and meta-analysis. Lancet Oncology. 2021, 22(9):1265-1274. (IF=54.433)

2. Li R#, Yang Z, Shao F, Cheng H, Wen Y, Sun S, Guo W, Li Z, Zhang F, Xue L, Bi N, Wang J, Sun Y, Li Y, Tan F, Xue Q, Gao S, Shi S*, Gao Y*, He J*. Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes. Nature Communications. 2021, 12(1):3785. (IF=17.694)

3. Yang X#, Shao F, Guo D, Wang W, Wang J, Zhu R, Gao Y*, He J*, Lu Z*. WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis. Cell Death & Disease. 2021, 12(5):462. (IF=9.685)

4. Wang W#, Shao F#, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y*, He J*, Lu Z*. METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding. Nature Communications. 2021, 12(1):3803. (IF=17.694)

5. Shao F#, Bian X#, Jiang H, Zhao G, Zhu L, Xu D, Wang S, Guo W, Xing D, Xue Q, Gao Y*, He J*, Lu Z*. Association of phosphoenolpyruvate carboxykinase 1 protein kinase activity-dependent sterol regulatory element-binding protein 1 activation with prognosis of oesophageal carcinoma. European Journal of Cancer. 2021, 142:123-131. (IF= 10.002)

6. Zhang H#, Guo W, Zhang F, Li R, Zhou Y, Shao F, Feng X, Tan F, Wang J, Gao S, Gao Y*, He J*. Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma. Frontiers in Oncology. 2020, 10:559568. (IF=6.244)

7. Yang Z#, Xu J, Li L, Li R, Wang Y, Tian Y, Guo W, Wang Z, Tan F, Ying J, Jiao Y, Gao S*, Wang J*, Gao Y*, He J*. Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma. Nature Communications. 2020, 11(1):4878. (IF=14.919)

8. Shao F#, Yang X, Wang W, Wang J, Guo W, Feng X, Shi S, Xue Q, Gao S, Gao Y*, Lu Z*, He J*. Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis. Cancer Communications. 2019, 39(1):54. (IF=5.627)

9. Wang C#, Li Z, Shao F, Yang X, Feng X, Shi S, Gao Y*, He J*. High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. Journal of Experimental & Clinical Cancer Research. 2017, 36(1):84. (IF=6.217)

10. Gao YB#, Chen ZL, Li JG, Hu XD, Shi XJ, Sun ZM, Zhang F, Zhao ZR, Li ZT, Liu ZY, Zhao YD, Sun J, Zhou CC, Yao R, Wang SY, Wang P, Sun N, Zhang BH, Dong JS, Yu Y, Luo M, Feng XL, Shi SS, Zhou F, Tan FW, Qiu B, Li N, Shao K, Zhang LJ, Zhang LJ, Xue Q, Gao SG, He J*. Genetic landscape of esophageal squamous cell carcinoma. Nature Genetics. 2014, 46(10):1097-102. (IF=29.352, C100)