方合志，教授，博士研究生導(dǎo)師。曾獲浙江省萬人計劃（青年拔尖人才 2020）、浙江省高校領(lǐng)軍人才培養(yǎng)計劃（高層次拔尖人才 2020）榮譽。獲得國家優(yōu)秀青年科學(xué)基金（2022，檢驗醫(yī)學(xué)方向）、浙江省杰出青年基金（2019，檢驗醫(yī)學(xué)方向）等項目資助。
      院校引進人才，2025年加入院校，曾在溫州醫(yī)科大學(xué)任教授（2021年起）。

近五年來，主持國家自然科學(xué)基金4項。承擔(dān)2項省部級科研項目，其中含省級重大項目1項。以第一/通訊作者發(fā)表論文30余篇（近5年20余篇），其中20余篇原創(chuàng)研究論文發(fā)表于Science Translational Medicine、Nature Communications、Cell Reports、Diabetes（2018, 2022）、Cell Discovery等國際權(quán)威期刊，申請或授權(quán)國家授權(quán)發(fā)明專利8項。牽頭撰寫《線粒體糖尿病臨床檢驗診斷專家共識》，參與制定2部遺傳性疾病診斷路徑專家共識。

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1.Wang B#, Han X#, Lin X#, Wang J#, You C, Chen K, Chen Y, Meng F, Jiang H, Zheng F, Zhang Y, Lyu J, Bai Y, Qu X, Zhou D, Jiang M*, Cui W*, Lyu J*, Fang H*.The Integral Membrane Protein SMIM4 Modulates Redox Balance via Malate Compartmentalization in Pancreatic Cancer. Nat Commun. 2025 (已接收待online, IF=15.7)

2. Xu X#, Li Y#, Sun S, Lin X, Zhang W, Wu Y, Wei B, Xu D, Zheng C, Fang H*, Cui W*.Circulating cytokine profiling and clustering identify biomarker predicting efficacy of ICI in combination with chemotherapy. Cancer Lett. 2025 631:217918. (IF=10.1)

3. Ren X#, Yan J#, Zhao Q, Bao X, Han X, Zheng C, Zhou Y, Chen L, Wang B, Yang L, Lin X, Liu D, Lin Y, Li M, Fang H*, Lu Z*, Lyu J*.The Fe-S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth. Cell Discov. 2023. 9(1):76. (IF=33.5)

4. Zhang K#, Chen L#, Wang B#, Chen D#, Ye X, Han X, Fang Q, Yu C, Wu J, Guo S, Chen L, Shi Y, Wang L, Cheng H, Li H, Shen L, Zhao Q, Jin L, Lyu J*, Fang H*.Mitochondrial supercomplex assembly regulates metabolic features and glutamine dependency in mammalian cells. Theranostics. 2023. 13(10):3165-3187. (IF=12.4)

5. Fang H#/*, Xie A#, Du M#, Li X, Yang K, Fu Y, Yuan X, Fan R, Yu W, Zhou Z, Sang T, Nie K, Li J, Zhao Q, Chen Z, Yang Y, Hong C*, Lyu J*. SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA. Sci Transl Med. 2022. 14(634):eabl6992. (IF=19.31)

6. Zhao Q#, Luo T#, Gao F#, Fu Y, Li B, Shao X, Chen H, Zhou Z, Guo S, Shen L, Jin L, Cen D, Zhou H*, Lyu J*, Fang H*.GRP75 Regulates Mitochondrial-Supercomplex Turnover to Modulate Insulin Sensitivity and Inflammatory Response. Diabetes. 2022. 71(2):233-248. (IF=9.33)

7. Fang H#/*, Ye X#, Xie J#, Li Y#, Li H, Bao X, Yang Y, Lin Z, Jia M, Han Q, Zhu J, Li X, Zhao Q, Yang Y, Lyu J*.A membrane arm of mitochondrial complex I sufficient to promote respirasome formation. Cell Reports. 2021. 35(2):108963. (IF=9.42)

8. Fang H#/*, Hu N, Zhao Q, Wang B, Zhou H, Fu Q, Shen L, Chen X, Shen F, Lyu J*.mtDNA Haplogroup N9a Increases the Risk of Type 2 Diabetes by Altering Mitochondrial Function and Intracellular Mitochondrial Signals. Diabetes. 2018. 67(7):1441-1453. (IF=7.2)