張沖，國家癌癥中心/中國醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院分子腫瘤學(xué)全國重點(diǎn)實(shí)驗(yàn)室研究員，博士研究生導(dǎo)師，助理教授。第一（含共同）作者的研究成果在《Nature》《Cancer Cell》等雜志發(fā)表，入選ESI Top1%高被引論文、細(xì)胞出報社2019中國年度論文。主持國家自然科學(xué)基金項(xiàng)目、醫(yī)科院創(chuàng)新工程人才養(yǎng)募基金項(xiàng)目，參與國家重點(diǎn)研發(fā)計劃等項(xiàng)目。
     院校引進(jìn)人才，2025年加入院校。2021年至2025年于北京大學(xué)生物醫(yī)學(xué)前沿創(chuàng)新中心（BIOPIC）任博雅博士后。

張沖研究組致力于運(yùn)用人工智能與生物信息學(xué)分析方法，結(jié)合細(xì)胞生物學(xué)實(shí)驗(yàn)方法，研究腫瘤癌前、發(fā)生發(fā)展、轉(zhuǎn)移復(fù)發(fā)等全周期中的基因組分子特征與演化模式，挖掘腫瘤發(fā)生發(fā)展過程中的規(guī)律，解決診斷、治療腫瘤過程中的難題，以期實(shí)現(xiàn)腫瘤的精準(zhǔn)診療。研究方向包括： 1）腫瘤的基因組及微環(huán)境 2）運(yùn)用克隆演化分析方法研究腫瘤的演進(jìn)過程 3）ecDNA在腫瘤發(fā)生發(fā)展及耐藥中的影響及作用

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1. Chen Lei#*, Zhang Chong#, Xue Ruidong#, Liu Mo#, Bai Jian, Bao Jinxia, Wang Yin, Jiang Nanhai, Li Zhixuan, Wang Wenwen, Wang Ruiru, Zheng Bo, Yang Airong, Hu Ji, Liu Ke, Shen Siyun, Zhang Yangqianwen, Bai Mixue, Wang Yan, Zhu Yanjing, Yang Shuai, Gao Qiang, Gu Jin, Gao Dong, Wang Xin Wei, Nakagawa Hidewaki, Zhang Ning, Wu Lin*, Rozen Steven George*, Bai Fan*, Wang Hongyang*. Deep whole-genome analysis of 494 hepatocellular carcinomas. Nature, 2024 Feb 14; 627(8004): 586–593. (IF = 50.5, ESI)

2. Xiang Xiao#, Liu Ziyang#, Zhang Chong#, Li Zhao#, Gao Jie, Zhang Changkun, Cao Qi, Cheng Jinghui, Liu Hengkang, Chen Dingbao, Cheng Qian, Zhang Ning, Xue Ruidong*, Bai Fan*, Zhu Jiye*. IDH mutation subgroup status shapes intratumor heterogeneity and the tumor microenvironment in intrahepatic cholangiocarcinoma. Adv. Sci., 2021 Jul 11; 8(17): 2101230. (IF=16.806)

3. Zhang Chong#, Zhang Lin#, Xu Tianlei#, Xue Ruidong#, Yu Liang#, Zhu Yuelu, Wu Yunlong, Zhang Qingqing, Li Dongdong, Shen Shuohao, Tan Dongfeng, Bai Fan*, Zhang Haizeng*. Mapping the spreading routes of lymphatic metastases in human colorectal cancer. Nat. Commun., 2020 Apr 24; 11(1): 1993. (IF=12.121)

4. Xue Ruidong#, Chen Lu#, Zhang Chong#, Fujita Masashi#, Li Ruoyan, Yan Shu-Mei, Ong Choon Kiat, Liao Xiwen, Gao Qiang, Sasagawa Shota, Li Yanmeng, Wang Jincheng, Guo Hua, Huang Qi-Tao, Zhong Qian, Tan Jing, Qi Lisha, Gong Wenchen, Hong Zhixian, Li Meng, Zhao Jingmin, Peng Tao, Lu Yinying, Lim Kiat Hon Tony, Boot Arnoud, Ono Atushi, Chayama Kazuaki, Zhang Zemin, Rozen Steve George, Teh Bin Tean, Wang Xin Wei, Nakagawa Hidewaki*, Zeng Mu Sheng*, Bai Fan*, Zhang Ning*. Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes. Cancer Cell, 2019 May 23; 35(6): 932–947. (IF=23.916, C100)