楊啟文，研究員，博士生導(dǎo)師，北京協(xié)和醫(yī)學(xué)院醫(yī)學(xué)博士。國(guó)家“萬人計(jì)劃”科技創(chuàng)新領(lǐng)軍人才，歐洲臨床微生物和感染病學(xué)會(huì)華人藥敏委員會(huì)（ChiCAST）主席、國(guó)家衛(wèi)生健康委臨床抗微生物藥物敏感性折點(diǎn)研究和標(biāo)準(zhǔn)制定專家委員會(huì)副主任委員。以第一完成人獲北京市科技進(jìn)步獎(jiǎng)二等獎(jiǎng)、麒麟科學(xué)技術(shù)獎(jiǎng)-科技創(chuàng)新獎(jiǎng)，并榮獲多項(xiàng)其他省部級(jí)科技獎(jiǎng)勵(lì)。主持國(guó)家科技重大專項(xiàng)、國(guó)家重點(diǎn)研發(fā)計(jì)劃、國(guó)家自然科學(xué)基金等多項(xiàng)國(guó)家級(jí)重大科研項(xiàng)目。其系統(tǒng)性的研究與實(shí)踐工作，顯著提升了我國(guó)感染性疾病的精準(zhǔn)診療與防控水平。

長(zhǎng)期致力于臨床重要致病菌的耐藥機(jī)制、分子流行病學(xué)及新型病原診斷技術(shù)研究。構(gòu)建了包含全國(guó)多中心監(jiān)測(cè)、耐藥機(jī)制研究、新藥評(píng)價(jià)、快速診斷研發(fā)及檢測(cè)標(biāo)準(zhǔn)化在內(nèi)的五大創(chuàng)新平臺(tái)體系。牽頭組建我國(guó)首個(gè)藥敏折點(diǎn)國(guó)際組織ChiCAST，設(shè)立自主知識(shí)產(chǎn)權(quán)藥敏折點(diǎn)，填補(bǔ)行業(yè)空白。以第一/通訊作者在《Lancet Microbe》等期刊發(fā)表SCI論文80余篇，累計(jì)影響因子達(dá)534.9。授權(quán)國(guó)內(nèi)外發(fā)明專利40項(xiàng)，成功研發(fā)并轉(zhuǎn)化多項(xiàng)快速檢測(cè)技術(shù)，產(chǎn)品銷售額超億元，廣泛應(yīng)用于臨床，為遏制細(xì)菌耐藥作出突出貢獻(xiàn)。

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1.Zhu Y#, Miao H#, Zhang J#, Jiang Z#, Chu X#, Xu Y, Tian W, Gao H, Zhu Y, Li L*, Yang Q*(corresponding author). Role of plasma and blood-cell co-metagenomic sequencing in precise diagnosis and severity evaluation of sepsis, a prospective cohort study in sepsis patients. J Infect. 2025 Jan 31:106434.（IF=14.3）

2.Jia X#, Zhu Y#, Jia P, Li C, Chu X#, Sun T, Liu X, Yu W, Chen F, Xu Y, Yang Q*(corresponding author). The key role of iroBCDN-lacking pLVPK-like plasmid in the evolution of the most prevalent hypervirulent carbapenem-resistant ST11-KL64 Klebsiella pneumoniae in China. Drug Resist Updat. 2024;77:101137.（IF=15.8）

3.Zhu Y#, Jia P, Yu W, Chu X, Liu X, Yang Q*(corresponding author). The epidemiology and virulence of carbapenem-resistant Pseudomonas aeruginosa in China. Lancet Microbe. 2023 Jun 13:S2666-5247(23)00113-1. （IF=86.21）

4.Yang XZ#, Sun TS#, Jia PY#, Li SJ#, Li XG, Shi Y, Li X, Gao H, Yin H, Jia XM*, Yang Q*(corresponding author). A-to-I RNA Editing in Klebsiella pneumoniae Regulates Quorum Sensing and Affects Cell Growth and Virulence. Adv Sci (Weinh). 2023 Apr 21:e2206056.（IF=17.52）

5.Yu W#, Zhang H#, Zhu Y, Jia P, Xu Y*, Yang Q*(corresponding author). In vitro activity of ceftolozane/tazobactam against Pseudomonas aeruginosa collected in the Study for Monitoring Antimicrobial Resistance Trends (SMART) between 2016-2019 in China. Int J Antimicrob Agents. 2023 Feb 1:106741. （IF=15.44）

6.Zhang D#, Zhang J#, Du J#, Zhou Y#, Wu P, Liu Z, Sun Z, Wang J, Ding W, Chen J, Wang J, Xu Y, Ouyang C*, Yang Q*(corresponding author). Optimized Sequencing Adaptors Enable Rapid and Real-Time Metagenomic Identification of Pathogens during Runtime of Sequencing. Clin Chem. 2022;68(6):826-836.. (IF=8.327)

7.Liu X#, Wu Y#, Zhu Y#, Jia P, Li X, Jia X, Yu W, Cui Y, Yang R, Xia W*, Xu Y*, Yang Q*(corresponding author). Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China. Emerg Microbes Infect. 2022, 11(1):648-661.(IF=19.568)

8.Jia X#, Li C#, Chen F#, Li X#, Jia P#, Zhu Y#, Sun T, Hu F, Jiang X, Yu Y, Hu B, Yang Q, Kang M, Liang H, Liao K, Hu L, Gu L, Jin Y, Duan Q, Zhang S, Sun Z, Huang W, He H, Shao H, Shan B, Zhuo C, Ji P, Zheng R, Li G, Xu Y, Yang Q*(corresponding author). Genomic epidemiology study of Klebsiella pneumoniae causing bloodstream infections in China. Clin Transl Med. 2021 Nov;11(11):e624. (IF=11.492)

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10.Yang Q#*(corresponding author), Jia X#, Zhou M#, Zhang H, Yang W, Kudinha T, Xu Y*. Emergence of ST11-K47 and ST11-K64 hypervirulent carbapenem- resistant Klebsiella pneumoniae in bacterial liver abscesses from China: a molecular, biological, and epidemiological study. Emerg Microbes Infect. 2020, 9(1):320-331. (IF=5.776)