張丹，研究員，博士生導(dǎo)師。2001年北京大學(xué)醫(yī)學(xué)部藥理學(xué)專業(yè)畢業(yè)，獲學(xué)士學(xué)位。本科畢業(yè)后進(jìn)入中國協(xié)和醫(yī)科大學(xué)藥物研究所藥理學(xué)專業(yè)碩博連讀，2006年獲得博士學(xué)位。2006年-2010年在美國NIH從事博士后研究工作，2010年進(jìn)入北京協(xié)和醫(yī)學(xué)院藥物研究所工作，主要從事神經(jīng)藥理相關(guān)研究。

長期從事神經(jīng)系統(tǒng)疾病的機(jī)制研究及靶標(biāo)發(fā)現(xiàn)，并基于天然產(chǎn)物開展創(chuàng)新藥物研發(fā)。獲得國內(nèi)外授權(quán)發(fā)明專利30余項。作為總負(fù)責(zé)人，主持研發(fā)治療帕金森氏病化學(xué)1.1類新藥芬樂胺，獲得臨床試驗批件并完成成果轉(zhuǎn)化。作為生物學(xué)負(fù)責(zé)人，研制了治療阿爾茨海默氏病中藥1類新藥GJ-4，并已完成成果轉(zhuǎn)化。發(fā)表論文60余篇。參編專著3部。培養(yǎng)博士、碩士10余名。曾獲教育部新世紀(jì)優(yōu)秀人才、北京市優(yōu)秀人才、北京市科技新星等獎勵。

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1. Shang M#, Ning J, Zang C, Ma J, Yang Y, Wan Z, Zhao J, Jiang Y, Chen Q, Dong Y, Wang J, Li F, Bao X*, and Zhang D*. Microbial metabolite 3-indolepropionic acid alleviated PD pathologies by decreasing enteric glia cell gliosis via suppressing IL-13Rα1 related signaling pathways. Acta Pharm Sin B. 2025;15(4):2024-2038. (IF= 14.6)

2. Shang M#, Ning J, Zang C, Ma J, Yang Y, Jiang Y, Chen Q, Dong Y, Wang J, Li F, Bao X*, and Zhang D*. FLZ attenuates Parkinson's disease pathological damage by increasing glycoursodeoxycholic acid production via down-regulating Clostridium innocuum. Acta Pharm Sin B. 2025;15(2):973-990. (IF=14.6)

3. Han Q#, Yang W#, Zang C#, Zhou L#, Zhang C, Bao X, Cai J, Li F, Shi Q, Wang X, Qu J*, Zhang D*, and Yu S*. The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin. Signal Transduct Target Ther. 2023;8(1):101. (IF=40.8)

4. Ju C#, Yuan F, Wang L, Zang C, Ning J, Shang M, Ma J, Li G, Yang Y, Chen Q, Jiang Y, Li F, Bao X, Zhang D*. Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway. Neurobiol Dis. 2023;177:105988. (IF=7.05)

5. Zang C#, Wang L, Yang H, Shang J, Liu H, Zhang Z, Ju C, Yuan F, Li F, Bao X, Zhang D*. HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson’s disease models. Acta Pharmacol Sin. 2022;43(2):285-294. (IF=7.169)

6. Zhao Z#, Ning J, Bao X, Shang M, Ma J, Li G, Zhang D*. Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis. Microbiome. 2021;9(1):226. (IF=16.837, ESI)

7. Zhao Z#, Li F, Ning J, Peng R, Shang J, Liu H, Shang M, Bao X, Zhang D*. Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-kB pathway through microbiota-gut-brain axis. Acta Pharm Sin B. 2021;11(9):2859-2879. (IF=14.907)

8. Shang J#, Ma S, Zang C, Bao X, Wang Y, Zhang D*. Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson’s disease treatment. Acta Pharm Sin B. 2021;11(5):1213-1226. (IF=14.907)

9. Zang C#, Liu H, Shang J, Yang H, Wang L, Sheng C, Zhang Z, Bao X, Yu Y, Yao X, Zhang D*. Gardenia jasminoides J.Ellis extract GJ-4 alleviated cognitive deficits of APP/PS1 transgenic mice. Phytomedicine. 2021;93:153780. (IF=6.656)

10.Hou L#, Sun F#, Huang R, Sun W, Zhang D*, and Wang Q*. Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model. Redox Biol. 2019;22:101134. (IF=9.98)