陳堅(jiān)，高級(jí)研究員，博士生導(dǎo)師，2003年本科畢業(yè)于北京大學(xué)生命科學(xué)學(xué)院生物科學(xué)專業(yè)，2011年取得美國(guó)德克薩斯大學(xué)西南醫(yī)學(xué)中心遺傳與發(fā)育學(xué)博士學(xué)位，2011年至2014年，在OriGene Technologies抗體部擔(dān)任研發(fā)總監(jiān)，2014年至2019年，在蘇州大學(xué)功能納米與軟物質(zhì)研究院任特聘教授，2019年7月加入北京腦科學(xué)與類腦研究所，現(xiàn)任高級(jí)研究員，2022年兼任昌平實(shí)驗(yàn)室領(lǐng)銜科學(xué)家，2024年7月加入中國(guó)醫(yī)學(xué)科學(xué)院北京腦和類腦研究院/北京協(xié)和醫(yī)學(xué)院腦和類腦學(xué)院，現(xiàn)任準(zhǔn)聘副教授。獲得國(guó)家重點(diǎn)研發(fā)計(jì)劃和國(guó)家自然科學(xué)基金等項(xiàng)目資助。

主要從事于神經(jīng)系統(tǒng)腫瘤和腫瘤遺傳學(xué)相關(guān)研究。發(fā)現(xiàn)免疫抑制中性粒細(xì)胞及其作用; 驗(yàn)證“腫瘤干細(xì)胞模型”并提供治療靶點(diǎn)證據(jù); 證明惡性膠質(zhì)瘤來源于神經(jīng)干/祖細(xì)胞; 揭示基因促骨肉瘤轉(zhuǎn)移機(jī)制及治療方案，拓展NF1在小腦發(fā)育中的新作用與治療思路，先后在Nature、Cell、Cancer Cell、Nature Cell Biology等國(guó)際期刊發(fā)表論文40余篇，論文他引超過8300次，h-index 26（Google scholar）,學(xué)術(shù)成果入選科學(xué)網(wǎng)評(píng)選的“2012年世界十大科技突破”。

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